Reference : Identification of large selective sweeps associated with major genes in cattle.
Scientific journals : Short communication
Life sciences : Genetics & genetic processes
Life sciences : Agriculture & agronomy
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/157868
Identification of large selective sweeps associated with major genes in cattle.
English
Druet, Tom mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Perez-Pardal, L. [> >]
Charlier, Carole mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Gautier, M. [> >]
2013
Animal Genetics
44
6
758-62
Yes (verified by ORBi)
International
0268-9146
1365-2052
United Kingdom
[en] bovine ; hidden Markov model ; selection signatures
[en] Selection for new favorable variants can lead to selective sweeps. However, such sweeps might be rare in the evolution of different species for which polygenic adaptation or selection on standing variation might be more common. Still, strong selective sweeps have been described in domestic species such as chicken lines or dog breeds. The goal of our study was to use a panel of individuals from 12 different cattle breeds genotyped at high density (800K SNPs) to perform a whole-genome scan for selective sweeps defined as unexpectedly long stretches of reduced heterozygosity. To that end, we developed a hidden Markov model in which one of the hidden states corresponds to regions of reduced heterozygosity. Some unexpectedly long regions were identified. Among those, six contained genes known to affect traits with simple genetic architecture such as coat color or horn development. However, there was little evidence for sweeps associated with genes underlying production traits.
http://hdl.handle.net/2268/157868
10.1111/age.12073
(c) 2013 The Authors, Animal Genetics (c) 2013 Stichting International Foundation for Animal Genetics.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
druet_animal_genetics2013.pdfPublisher postprint249.97 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.