Photochemical properties and activity of water-soluble polymer/C60 nanohybrids for photodynamic therapy

[en] Water-soluble star-like poly(vinyl alcohol)/C60 and poly{[poly(ethylene glycol) acrylate]-co- (vinyl acetate)}/C60 nanohybrids are prepared by grafting macroradicals onto C60 and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) of the polymeric arms respectively impact the photodynamic activity and the stealthiness of the nanohybrids. The advantages of both nanohybrids are encountered in a third one, poly[(Nvinylpyrrolidone)- co-(vinyl acetate)]/C60, which has linear grafts without hydroxyl groups, and shows a better photodynamic activity.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Hurtgen, Marie ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Debuigne, Antoine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Hoebeke, Maryse ; Université de Liège - ULiège > Department of Physics > Laboratory of Biomedical Spectroscopy

Passirani, Catherine; University of Angers > INSERM U 646

Lautram, Nolwenn; University of Angers > INSERM U 646

Mouithys-Mickalad, Ange ; Université de Liège - ULiège > Center for Oxygen Research and Development

Guelluy, Pierre-Henri; Université de Liège - ULiège > Department of Physics > Laboratory of Biomedical Spectroscopy

Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Detrembleur, Christophe ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Photochemical properties and activity of water-soluble polymer/C60 nanohybrids for photodynamic therapy

Publication date :

January 2013

Journal title :

Macromolecular Bioscience

ISSN :

1616-5187

eISSN :

1616-5195

Publisher :

John Wiley & Sons, United Kingdom

Volume :

Issue :

Pages :

106-115

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200251/abstract

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique

Available on ORBi :

since 11 October 2013

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