Reference : Bioactive Intraocular Lens – A Strategy to Control Secondary Cataract
Scientific congresses and symposiums : Paper published in a journal
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Biotechnology
http://hdl.handle.net/2268/156794
Bioactive Intraocular Lens – A Strategy to Control Secondary Cataract
English
Huang, Yi-Shiang mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Bertrand, Virginie mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Bozukova, Dimitriya mailto [PhysIOL, SA, Belgium > > > >]
Pagnoulle, Christophe mailto [PhysIOL, SA, Belgium > > > >]
De Pauw, Edwin mailto [Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Durrieu, Marie-Christine mailto [Institut Européen de Chimie et Biologie, University of Bordeaux I, Pessac, France > CBMN UMR5248 > > >]
2014
IFMBE Proceedings
Springer
41
XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013
1605-1608
Yes
International
Heidelberg
Germany
xiii Mediterranean conference on Medical and Biological engineering and computing 2013
From 25-09-2013 to 28-09-2013
Seville
Spain
[en] Intraocular Lens ; RGD Peptide ; Secondary Catatract ; Posterior Capsular Opacification ; Lens Epithelial Cells
[en] Cataract is the opacity of the lens, causing impairment of vision or even blindness. Today, a surgery is still the only available treatment. The intraocular lens (IOL) is a polymer implant designed to replace the natural lens in the cataract surgery. However, the bioinert materials could not satisfy the unmet need in the secondary cataract control. Posterior capsular opacification (PCO, or Secondary Cataract), characterized by a thick and cloudy layer of lens epithelial cells (LECs), is the most common postoperative complication.

In our research, a bioactive molecule is immobilized onto the conventional acrylic hydrophilic polymer pHEMA (Poly(2-hydroxyethyl methacrylate)) using oxygen plasma treatment followed by deposition. The RGD peptide sequence, being well-known for its ability to promote cellular attachment by binding to integrin receptors, is designed to stimulate the adhesion of LECs on the IOL. Our data show the peptide immobilized biomaterial not only exhibits similar optical property, but also reveals enhanced biological properties in cell adhesion and cell morphology maintenance. By means of surface functionalization of IOL to stimulate LECs adhesion, the secondary cataract could be controlled.
Walloon region, Belgium
LINOLA, 1117465
http://hdl.handle.net/2268/156794
10.1007/978-3-319-00846-2_396

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