Performance evaluation and X-ray dose quantification for various scanning protocols of the GE eXplore 120 micro-CT

Bretin, Florian; Warnock, Geoffrey; Luxen, André; Plenevaux, Alain; Seret, Alain; Bahri, Mohamed Ali

doi:10.1109/TNS.2013.2279180

Request a copy

Article (Scientific journals)

Performance evaluation and X-ray dose quantification for various scanning protocols of the GE eXplore 120 micro-CT

Bretin, Florian; Warnock, Geoffrey; Luxen, André et al.

2013 • In IEEE Transactions on Nuclear Science, 60 (5), p. 3235-3241

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/155693

DOI
10.1109/TNS.2013.2279180

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

IEEE_TNS_ Bretin_Performance_Explore120_ 2013.pdf

Publisher postprint (1.25 MB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Dosimetry; Performance evaluation; X-ray tomography

Abstract :

[en] The aim of this study was to evaluate the performance of the General Electric eXplore 120 micro-CT regarding image quality and delivered dose of several protocols. Image quality (resolution, linearity, uniformity and geometric accuracy) was assessed using the vmCT phantom developed for the GE eXplore Ultra, the QRM low contrast and the QRM Bar Pattern Phantom. All dose measurements were performed using a mobileMOSFET dose verification system and the CTDI100 and the MSAD were determined with a custom built PMMA phantom. Additionally, in vivo scans in sacrificed rats with different weights were acquired to assess dose, contrast and resolution variation due to X-ray absorption in surrounding tissue. The spatial resolution was determined as between 95 and 138 μm with a geometric accuracy of 0.1%. The system has a highly linear response to the iodine concentrations (0.937 to 30 mg/ml) for all protocols. The calculated CTDI100 ranged from 20.15 to 56.79 mGy and the MSAD from 27.98 to 77.45 mGy. The results were confirmed by in vivo scans in rats with different weights and no impact of body weight on delivered dose could be observed. However, body weight had a slight impact on image contrast and resolution.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Bretin, Florian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Warnock, Geoffrey

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse

Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron

Seret, Alain ; Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale

Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron

Language :

English

Title :

Performance evaluation and X-ray dose quantification for various scanning protocols of the GE eXplore 120 micro-CT

Publication date :

October 2013

Journal title :

IEEE Transactions on Nuclear Science

ISSN :

0018-9499

Publisher :

IEEE, New York, United States - New York

Volume :

Issue :

Pages :

3235-3241

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://ieeexplore.ieee.org/xpl/articleDetails.jsp?tp=&arnumber=6616643&queryText%3Dbretin

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 10 September 2013

Statistics

Number of views

103 (25 by ULiège)

Number of downloads

2 (2 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

M. J. Paulus, "High resolution X-ray computed tomography: an emerging tool for small animal cancer res," Neoplasia, vol. 2, no. 1-2, pp. 62-70, Jan. 2000. (Pubitemid 30123181)
N. M. D. Clerck, "High-resolution X-ray microtomography for the detection of lung tumors in living mice," Neoplasia, vol. 6, no. 4, pp. 374-379, Jul. 2004.
N. Ford, "Fundamental image quality limits formicrocomputed tomography in small animals," Med. Phys., vol. 30, no. 11, pp. 2869-2877, Oct. 2003. (Pubitemid 37444296)
L. O. T. Gainkam, "Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole spect/micro-CT," J. Nucl. Med., vol. 49, no. 5, pp. 788-795, Apr. 2008. (Pubitemid 351717545)
C. H. Chang, "Longitudinal evaluation of tumormetastasis by an FDGmicroPet/ microCT dual-imagingmodality in a lung carcinoma-bearing mouse model," Anticancer Res., vol. 26, no. 1A, pp. 159-166, Jan. 2006.
V. Kersemans, "Micro-CT for anatomic referencing in PET and SPECT: radiation dose, biologic damage, and image quality," J. Nucl. Med., vol. 52, no. 11, pp. 1827-1833, Oct. 2011.
E. L. Ritman, "Micro-computed tomography-current status and develop," Annu. Rev. Biomed. Eng., vol. 6, no. 1, pp. 185-208, Aug. 2004.
S. Chen, "Low-dose whole-body irradiation (LD-WBI) changes protein expression of mouse thymocytes: Effect of a LD-WBI-enhanced protein Rip10 on cell proliferation and spontaneous or radiation-induced thymocyte apoptosis," Toxicol. Sci., vol. 55, no. 1, pp. 97-106, May 2000. (Pubitemid 30252440)
H. Wan, "Effects of low dose radiation on signal transduction of neurons in mouse hypothalamus," Biomed. Environ. Sci., vol. 14, no. 3, pp. 248-255, 2001. (Pubitemid 33658910)
S. A. Detombe, "X-ray dose delivered during a longitudinal micro-CT study has no adverse effect on cardiac and pulmonary tissue in C57BL/6 mice," Acta Radiol., vol. 54, no. 4, pp. 435-441, May 2013.
L. Y. Du, "A quality assurance phantomfor the performance evaluation of volumetric micro-CT systems," Phys.Med. Biol., vol. 52, no. 23, pp. 7087-7108, Nov. 2007. (Pubitemid 350150633)
W. Kalender, "Comparative evaluation: Acceptance testing and constancy testing for micro-CT scanners," Biomed. Tech., vol. 50, no. 2, pp. 1192-1193, 2005.
O. Langner, "Bar and point test patterns generated by dry-etching for measurement of high spatial resolution in micro-CT," in Proc. IFMBE, 2009, pp. 428-431.
M. M. Rehani, "Managing patient dose in computed tomography," Ann. ICRP, vol. 30, no. 4, pp. 7-45, Oct. 2000.
M. Hupfer, "Dosimetry concepts for scanner quality assurance and tissue dose assessment in micro-CT," Med. Phys., vol. 39, no. 2, pp. 658-670, Jan. 2012.
M. A. Bahri, "Performance evaluation of the general electric eXplore ct 120 micro-CT using the vmCT phantom," Nucl. Instrum. Methods Phys. Res. A, vol. 648, pp. S181-S185, Aug. 2011.
L. Feldkamp, "Practical cone-beam algorithm," J. Opt. Soc. Amer. A, vol. 1, no. 6, pp. 612-619, Jun. 1984.
M. A. Bahri, "Performance evaluation of the GE eXplore CT 120 micro-CT for various scanning protocols," in Proc. IEEE NSS/MIC, 2012, pp. 3783-3785, M21-18.
K. Jessen, "Dosimetry for optimisation of patient protection in computed tomography," Appl. Radiat. Isot., vol. 50, no. 1, pp. 165-172, Jan. 1999. (Pubitemid 29048998)
J. A. Bauhs, "CT dosimetry: Comparison of measurement techniques and Devices1," Radiographics, vol. 28, no. 1, pp. 245-253, Jan. 2008.
F. Bretin, "X-ray dose quantification for various scanning protocols with the GE eXplore 120 micro-CT," in Proc. IEEE NSS/MIC, 2012, pp. 3775-3777.
I. Willekens, "Evaluation of the radiation dose in microCT with optimization of the scan protocol," Contrast Media Mol. Imag., vol. 5, no. 4, pp. 201-207, Jul. 2010.