[en] Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk.
Research Center/Unit :
d‐BRU - Dental Biomaterials Research Unit - ULiège
Disciplines :
General & internal medicine
Author, co-author :
NEUPREZ, Audrey ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Coste, S
Rompen, Eric ; Université de Liège - ULiège > Département de sciences dentaires > Chirurgie bucco-dentaire et parodontologie
Crielaard, Jean-Michel ; Université de Liège - ULiège > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques
REGINSTER, Jean-Yves ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Language :
English
Title :
Osteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
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