Article (Scientific journals)
Oral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome.
Kearns, S. R.; Daly, Adrian; Sheehan, K. et al.
2004In Journal of Bone and Joint Surgery, British Volume, 86 (6), p. 906-11
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Keywords :
Administration, Oral; Animals; Ascorbic Acid/administration & dosage; Compartment Syndromes/complications/enzymology; Edema; Intercellular Adhesion Molecule-1/metabolism; Muscle, Skeletal/blood supply/enzymology; Peroxidase/metabolism; Rats; Rats, Sprague-Dawley; Reperfusion Injury/enzymology/prevention & control
Abstract :
[en] Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury. Vitamin C is a powerful antioxidant which concentrates preferentially in leucocytes and attenuates reperfusion-induced muscle injury. We have evaluated the use of pretreatment with oral vitamin C in the prevention of injury caused by compartment syndrome in a rat cremasteric muscle model. Acute and delayed effects of pretreatment with vitamin C were assessed at one and 24 hours after decompression of compartment syndrome. Muscle function was assessed electrophysiologically. Vascular, cellular and tissue inflammation was assessed by staining of intercellular adhesion molecule-1 (ICAM-1) and by determination of the activity of myeloperoxidase (MPO) in neutrophils and tissue oedema. Compartment syndrome impaired skeletal muscle function and increased the expression of ICAM-1, activity of MPO and muscle weight increased significantly. Pretreatment with vitamin C preserved muscle function and reduced the expression of ICAM-1, infiltration of the neutrophils and oedema.
Disciplines :
Immunology & infectious disease
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Kearns, S. R.
Daly, Adrian  ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Sheehan, K.
Murray, P.
Kelly, C.
Bouchier-Hayes, D.
Language :
English
Title :
Oral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome.
Publication date :
2004
Journal title :
Journal of Bone and Joint Surgery, British Volume
ISSN :
0301-620X
Publisher :
British Editorial Society of Bone and Joint Surgery, United Kingdom
Volume :
86
Issue :
6
Pages :
906-11
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 August 2013

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