Article (Scientific journals)
The role of epigenetics in malignant pleural mesothelioma
Vandermeers, Fabian; Neelature Sriramareddy, Sathyanarayana; Chrisostome, Costa et al.
2013In Lung Cancer, 81, p. 311-318
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Keywords :
Mesothelioma; Epigenetics; DNA methylation; Histone acetylation
Abstract :
[en] Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic errors leading to inadequate gene expression in tumor cells. The availability of compounds that modulate epigenetic modifications, such as histone acetylation or DNA methylation, offers new prospects for treatment of MPM. Here, we review latest findings on epigenetics in mesothelioma and present novel strategies for promising epigenetic thérapies.
Disciplines :
Author, co-author :
Vandermeers, Fabian
Neelature Sriramareddy, Sathyanarayana ;  Université de Liège - ULiège
Chrisostome, Costa
Hubaux, Roland
Cosse, Jean-Philippe ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
Title :
The role of epigenetics in malignant pleural mesothelioma
Publication date :
Journal title :
Lung Cancer
Publisher :
Elsevier Scientific, Limerick, Ireland
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
This work was supported by the “Fonds National de la Recherche Scientifique” (FNRS), the Télévie, the Belgian Foundation against Cancer, the Sixth Research Framework Programme of the European Union (project INCA LSHC-CT-2005-018704), the “Neoangio” excellence program and the “Partenariat Public Privé” PPP INCA of the “Direction générale des Technologies, de la Recherche et de l’Energie/DG06” of the Walloon government, the “Action de Recherche Concertée Glyvir” of the “Communauté franc¸ aise de Belgique”, the “Centre anticancéreux près ULg” (CAC), the “Synbiofor” project of GxABT, the “ULg Fonds Spéciaux pour la Recherche”, the “Plan Cancer” of the “Service Public Fédéral,” and the Interuniversity Attraction Poles (IAP) Program BELVIR initiated by the Belgian Science Policy Office.
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