The role of epigenetics in malignant pleural mesothelioma

[en] Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic errors leading to inadequate gene expression in tumor cells. The availability of compounds that modulate epigenetic modifications, such as histone acetylation or DNA methylation, offers new prospects for treatment of MPM. Here, we review latest findings on epigenetics in mesothelioma and present novel strategies for promising epigenetic thérapies.

Disciplines :

Oncology

Author, co-author :

Vandermeers, Fabian

Neelature Sriramareddy, Sathyanarayana ; Université de Liège - ULiège

Chrisostome, Costa

Hubaux, Roland

Cosse, Jean-Philippe ; Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire

Willems, Luc ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.

Language :

English

Title :

The role of epigenetics in malignant pleural mesothelioma

Publication date :

2013

Journal title :

Lung Cancer

ISSN :

0169-5002

eISSN :

1872-8332

Publisher :

Elsevier Scientific, Limerick, Ireland

Volume :

Pages :

311-318

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

This work was supported by the “Fonds National de la Recherche Scientifique” (FNRS), the Télévie, the Belgian Foundation against Cancer, the Sixth Research Framework Programme of the European Union (project INCA LSHC-CT-2005-018704), the “Neoangio” excellence program and the “Partenariat Public Privé” PPP INCA of the “Direction générale des Technologies, de la Recherche et de l’Energie/DG06” of the Walloon government, the “Action de Recherche Concertée Glyvir” of the “Communauté franc¸ aise de Belgique”, the “Centre anticancéreux près ULg” (CAC), the “Synbiofor” project of GxABT, the “ULg Fonds Spéciaux pour la Recherche”, the “Plan Cancer” of the “Service Public Fédéral,” and the Interuniversity Attraction Poles (IAP) Program BELVIR initiated by the Belgian Science Policy Office.

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since 22 August 2013

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