Effectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial

[en] AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD) have been conducted. We assessed the effectiveness of a pharmaceutical care program for patients with COPD. METHODS: The PHARMACOP-trial is a single-blind 3-month RCT, conducted in 170 community pharmacies in Belgium, enrolling patients prescribed daily COPD medication, aged >/=50 years, and with a smoking history >/=10 pack-years. A computer-generated randomization sequence allocated patients to intervention (n=371), receiving protocol-defined pharmacist care, or control group (n=363), receiving usual pharmacist care (1:1 ratio, stratified by center). Interventions, focusing on inhalation technique and adherence to maintenance therapy, were carried out at start of the trial and at one month follow-up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnea, COPD specific and generic health status and smoking behavior. RESULTS: From December 2010 to April 2011, 734 patients were enrolled. 42 patients (5.7%) were lost to follow-up. At the end of the trial, inhalation score (Mean estimated difference [Delta],13.5%; 95% Confidence Interval [CI], 10.8-16.1; P<.0001) and medication adherence (Delta, 8.51%; 95%CI, 4.63-12.4; P<.0001) were significantly higher in the intervention group compared to the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 vs 35; Rate Ratio, 0.28; 95%CI, 0.12-0.64; P=.003). No other significant between-group differences were observed. CONCLUSION: Pragmatic pharmacist care programs improve the pharmacotherapeutic regime in patients with COPD and could reduce hospitalization rates.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Tommelein, Eline

Mehuys, Els

Van Hees, Thierry ; Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière

Adriaens, Els

Van Bortel, Luc

Christiaens, Thierry

Van Tongelen, Inge

Remon, Jean-Paul

Boussery, Koen

Brusselle, Guy

Language :

English

Title :

Effectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial

Publication date :

2014

Journal title :

British Journal of Clinical Pharmacology

ISSN :

0306-5251

eISSN :

1365-2125

Publisher :

Blackwell, Oxford, United Kingdom

Volume :

Issue :

Pages :

756-766

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 22 August 2013

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Scopus citations^®

123

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120

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