Article (Scientific journals)
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
Eddahri, Fouad; Denanglaire, Sebastien; Bureau, Fabrice et al.
2009In Blood, 113 (11), p. 2426-2433
Peer Reviewed verified by ORBi
 

Files


Full Text
EddahriF_Blood_2009.pdf
Publisher postprint (1.36 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Tnf; inflammation; nicotinamide
Abstract :
[en] The conditions leading to the activation/differentiation of T-helper (Th) cells dedicated for B-cell antibody production are still poorly characterized. We now demonstrate that interleukin-6 (IL-6) promotes the differentiation of naive T lymphocytes into helper cells able to promote B-cell activation and antibody secretion. IL-6-driven acquisition of B-cell help capacity requires expression of the signal transducer and activator of transcription 3 (STAT3), but not STAT4 or STAT6 transcription factors, suggesting that the ability to provide help to B cells is not restricted to a well-defined Th1 or Th2 effector population. T cell-specific STAT3-deficient mice displayed reduced humoral responses in vivo that could not be related to an altered expansion of CXCR5-expressing helper T cells. IL-6 was shown to promote IL-21 secretion, a cytokine that was similarly found to promote the differentiation of naive T cells into potent B-cell helper cells. Collectively, these data indicate that the ability to provide B-cell help is regulated by IL-6/IL-21 through STAT3 activation, independently of Th1, Th2, Th17, or follicular helper T cell (T(FH)) differentiation
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Eddahri, Fouad
Denanglaire, Sebastien
Bureau, Fabrice ;  Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire
Spolski, Rosanne
Leonard, Warren J
Leo, Oberdan
Andris, Fabienne
Language :
English
Title :
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
Publication date :
2009
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Volume :
113
Issue :
11
Pages :
2426-2433
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 June 2009

Statistics


Number of views
99 (7 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
166
Scopus citations®
without self-citations
156
OpenCitations
 
151

Bibliography


Similar publications



Contact ORBi