Effects of percutaneous estradiol–oral progesterone versus oral conjugated equine estrogens–medroxyprogesterone acetate on breast cell proliferation and bcl-2 protein in healthy women
Murkes, Daniel; Conner, P; Leifland, Ket al.
2011 • In Fertility and Sterility, 95 (3), p. 1188-91
[en] In a prospective, randomized clinical study 77 women were assigned randomly to receive sequential hormone therapy with either conventional oral conjugated equine estrogens (0.625 mg) with the addition on 14 of the 28 days of oral medroxyprogesterone acetate (5 mg) or natural E(2) gel (1.5 mg) with oral micronized P (200 mg) on 14 of the 28 days of each cycle. Because oral conjugated equine estrogens-medroxyprogesterone acetate induced a highly significant increase in breast cell proliferation in contrast to percutaneous E(2)-oral P with a difference between therapies approaching significance, the former therapy has a marked impact on the breast whereas natural percutaneous E(2)-oral micronized P has not.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Murkes, Daniel; Department of Obstetrics and Gynecology, Södertälje Hospital, Södertälje, Sweden
Conner, P; Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
Leifland, K; Unilabs Mammography, Capio St. Göran’s Hospital, Stockholm, Sweden
Tani, E; Department of Pathology and Cytology, Karolinska Hospital, Stockholm, Sweden
BELIARD, Aude ; Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Lundström, E; Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
Söderkvist, G; Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
Language :
English
Title :
Effects of percutaneous estradiol–oral progesterone versus oral conjugated equine estrogens–medroxyprogesterone acetate on breast cell proliferation and bcl-2 protein in healthy women
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