Reference : G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p5...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.
Doumont, Gilles [> > > >]
Martoriati, Alain [> > > >]
Beekman, Chantal [> > > >]
Bogaerts, Sven [> > > >]
Mee, Patrick J [> > > >]
Bureau, Fabrice mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Colombo, Emanuela [> > > >]
Alcalay, Myriam [> > > >]
Bellefroid, Eric J. [> > > >]
Marchesi, Francesco [> > > >]
Scanziani, Eugenio [> > > >]
Pelicci, Pier Giuseppe [> > > >]
Marine, Jean-Christophe [> > > >]
EMBO Journal
Oxford University Press
Yes (verified by ORBi)
United Kingdom
[en] DNA damage ; growth arrest ; p53 ; Ptprv ; skin
[en] In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new direct p53 target, Ptprv (or ESP), encoding a transmembrane tyrosine phosphatase. Ptprv transcription is dramatically and preferentially increased in cultured cells undergoing p53-dependent cell cycle arrest, but not in cells undergoing p53-mediated apoptosis. This observation was further confirmed in vivo using a Ptprv null-reporter mouse line. A p53-responsive element is present in the Ptprv promoter and p53 is recruited to this site in vivo. Importantly, while p53-dependent apoptosis is intact in mice lacking Ptprv, Ptprv-null fibroblasts and epithelial cells of the small intestine are defective in G1 checkpoint control. Thus, Ptprv is a new direct p53 target and a key mediator of p53-induced cell cycle arrest. Finally, Ptprv loss enhances the formation of epidermal papillomas after exposure to chemical carcinogens, suggesting that Ptprv acts to suppress tumor formation in vivo.
Researchers ; Professionals

File(s) associated to this reference

Fulltext file(s):

Restricted access
DumontG_EMBO_2005.pdfDemander un tiré à partPublisher postprint368.23 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.