Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy.

Atrial Function, Left; Cardiomyopathy, Hypertrophic/complications/ultrasonography; Echocardiography/methods; Elasticity Imaging Techniques/methods; Female; Heart Atria/ultrasonography; Heart Failure/etiology/ultrasonography; Humans; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic

Abstract :

[en] BACKGROUND: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional speckle tracking echocardiography and its relation with left ventricular (LV) function and clinical status in patients with HCM. METHODS: We prospectively enrolled 37 consecutive patients with HCM and 37 normal subjects with similar age and gender distribution. Longitudinal LV strain (epsilon) and LA epsilon and strain rate (Sr) parameters (systolic, early diastolic, and late diastolic during atrial contraction) were assessed. RESULTS: Peak LAepsilon and LA Sr parameters were significantly lower in patients compared with controls (P </= .001 for all). In patients, all LA function parameters correlated with LVepsilon (P < .003 for all). Indexed LA volume, LA function parameters, and mitral regurgitation degree were the main correlates of New York Heart Association class; late diastolic strain rate during atrial contraction was the only independent predictor of symptomatic status. CONCLUSION: In patients with HCM, LA function is significantly reduced and related to LV dysfunction. Moreover, LA booster pump function emerged as an independent correlate of heart failure symptoms in this setting.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Rosca, Monica

Popescu, Bogdan Alexandru

Beladan, Carmen C.

Calin, Andreea

Muraru, Denisa

Popa, Elena C.

LANCELLOTTI, Patrizio ; Centre Hospitalier Universitaire de Liège - CHU > Cardiologie

Enache, Roxana

Coman, Ioan M.

Jurcut, Ruxandra

Ghionea, Mihai

Ginghina, Carmen

Language :

English

Title :

Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy.

Publication date :

2010

Journal title :

Journal of the American Society of Echocardiography

ISSN :

0894-7317

eISSN :

1097-6795

Publisher :

C.V. Mosby Company, United States - Missouri

Volume :

Issue :

Pages :

1090-8

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 21 June 2013

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Scopus citations^®

104

Scopus citations^®
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OpenCitations

OpenAlex citations

105

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