Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Musat, E.; Roelofs, E.; Bar-Deroma, R.; Fenton, P.; GULYBAN, Akos; Collette, L.; Stupp, R.; Weber, D. C.; Davis, J. B.; Aird, E.; Baumert, B. G.

doi:10.1016/j.radonc.2010.03.005

Article (Scientific journals)

Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Musat, E.; Roelofs, E.; Bar-Deroma, R. et al.

2010 • In Radiotherapy and Oncology, 95 (2), p. 218-224

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/150884

DOI
10.1016/j.radonc.2010.03.005

PubMed
20378192

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Musat et al. - 2010 - Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033 First evaluation of quality of radiotherapy planning. - Radiother Oncol.pdf

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Keywords :

Conformal radiotherapy; Conformity indices; Dummy run; Homogeneity; Low-grade gliomas; Quality assurance; Adult; Antineoplastic Agents, Alkylating; Central Nervous System Neoplasms; Dacarbazine; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Staging; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; Treatment Outcome

Abstract :

[en] Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF× CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV Dmin, improving CF. U correlated with PTV Dmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue. © 2010 Elsevier Ireland Ltd. All rights reserved.

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Musat, E.; Radiation-Oncology Department, Institute Curie, René Huguenin Hospital, 35 Rue Dailly, 92210 Saint-Cloud, France, Radiation-Oncology Department, Maastricht University Medical Centre (MUMC), Netherlands

Roelofs, E.; Radiation-Oncology Department, Maastricht University Medical Centre (MUMC), Netherlands

Bar-Deroma, R.; Oncology Department, Rambam Medical Center, Haifa, Israel

Fenton, P.; EORTC Headquarters, Brussels, Belgium

GULYBAN, Akos ; Centre Hospitalier Universitaire de Liège - CHU > Radiothérapie

Collette, L.; EORTC Headquarters, Brussels, Belgium

Stupp, R.; Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland

Weber, D. C.; Radiation Oncology Department, Geneva University Hospital, Switzerland

Davis, J. B.; Radiation Oncology Clinic and Policlinic, University Hospital, Zurich, Switzerland

Aird, E.; Medical Physics Department, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom

Baumert, B. G.; Radiation-Oncology Department, Maastricht University Medical Centre (MUMC), Netherlands

Language :

English

Title :

Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

Publication date :

2010

Journal title :

Radiotherapy and Oncology

ISSN :

0167-8140

eISSN :

1879-0887

Publisher :

Elsevier Scientific, Limerick, Ireland

Volume :

Issue :

Pages :

218-224

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 20 June 2013

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Bibliography

Bentzen SM. Towards evidence based radiation oncology: improving the design, analysis, and reporting of clinical outcome studies in radiotherapy. Radiother Oncol 1998;46: 5-18. (Pubitemid 28072852)
Karim AB, Afra D, Cornu P, et al. Randomised trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: EORTC 22845 with MRC BRO4 study: an interim analysis. Int J Radiat Oncol Biol Phys 2002;52: 316-24.
Karim AB, Maat B, Hatlevoll R, et al. A randomised trial on dose-response in radiation therapy of low-grade cerebral glioma: EORTC 22844. Int J Radiat Oncol Biol Phys 1996;36: 549-56.
Pace A, Vidiri A, Galie E, et al. Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response. Ann Oncol 2003;14: 1722-6. (Pubitemid 38029042)
Shaw E, Arusell R, Scheithauer B, et al. Prospective randomised trial of lowversus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a NCCTG/RTOG/ECOG study. J Clin Oncol 2002;20: 2267-76.
Horiot JC, Johansson KA, Gonzalez DG, et al. Quality assurance control in the EORTC cooperative group of radiotherapy. 1. Assessment of radiotherapy staff and equipment. Radiother Oncol 1986;6: 275-84. (Pubitemid 16026733)
Bernard Davis J, Reiner B, Dusserre A, et al. Quality assurance of the EORTC trial 22911. A phase III study of post-operative external radiotherapy in pathological stage T3N0 prostatic carcinoma: the dummy run. Radiother Oncol 2002;64: 65-73. (Pubitemid 35223155)
Ataman F, Poortmans P, Stupp R, et al. Quality assurance of the EORTC 26981/ 22981; NCIC CE3 intergroup trial on radiotherapy with or without temozolomide for newly-diagnosed glioblastoma multiforme: the individual case review. Eur J Cancer 2004;40: 1724-30. (Pubitemid 38902908)
Matzinger O, Poortmans P, Giraud J-Y, et al. Quality assurance in the 22991 EORTC ROG trial in localized prostate cancer: dummy run and individual case review. Radiother Oncol 2009;90: 285-90.
Budiharto T, Musat E, Poortmans P, et al. Profile of radiotherapy departments contributing to the EORTC Radiation Oncology Group (ROG) in the 21st century. Radiother Oncol 2008;88: 403-10.
Feuvret L, Noel G, Mazeron JJ, Bey P. Conformity index: a review. Int J Radiat Oncol Biol Phys 2006;64: 333-42. (Pubitemid 43083417)
Oozeer R, Chauvet B, Garcia R, et al. Dosimetric evaluation of conformal radiotherapy: conformity factor. Cancer Radiother 2000;4: 207-16. (Pubitemid 30415401)
van't Riet A, Mak AC, Moerland MA, et al. A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: application to the prostate. Int J Radiat Oncol Biol Phys 1997;37: 731-6. (Pubitemid 27175329)
Yoon M, Park SY, Shin D, et al. A new homogeneity index based on statistical analysis of the dose-volume histogram. J Appl Clin Med Phys 2007;8: 9-17.
De Meerleer GO, Vakaet LA, De Gersem WR, et al. Radiotherapy of prostate cancer with or without intensity modulated beams: a planning comparison. Int J Radiat Oncol Biol Phys 2000;47: 639-48. (Pubitemid 30317481)
ICRU Report 50. Prescribing, recording and reporting photon beam radiotherapy. Report 50. Bethesda, MD, USA; 1993.
ICRU Report 62. Supplement to ICRU Report 50. Med Phys 1998;25.
Knoos T, Kristensen I, Nilsson P. Volumetric and dosimetric evaluation of radiation treatment plans: radiation conformity index. Int J Radiat Oncol Biol Phys 1998;42: 1169-76. (Pubitemid 29004164)
Lomax NJ, Scheib SG. Quantifying the degree of conformity in radiosurgery treatment planning. Int J Radiat Oncol Biol Phys 2003;55: 1409-19. (Pubitemid 36338310)
Lefkopoulos D, Schlienger M, Touboul E, et al. Quantitative evaluation of treatment planning for linac multi-isocentric radiosurgery. In: Proceedings of the XIth international conference on ''computers in radiation therapy, " XIth ICCR, Manchester, UK; 1994. p.296-7.
Hammer O, Harper DAT, Ryan PD. PAST: statistics software package for education, data analysis. Palaeontol Electron 2001;4: 9.
Jiang SB, Sharp GC, Neicu T, et al. On dose distribution comparison. Phys Med Biol 2006;51: 759-76.
Wu VW, Kwong DL, Sham JS. Target dose conformity in 3-dimensional conformal radiotherapy and intensity modulated radiotherapy. Radiother Oncol 2004;71: 201-6. (Pubitemid 38521189)
Brahme A. Individualizing cancer treatment: biological optimization models in treatment planning and delivery. Int J Radiat Oncol Biol Phys 2001;49: 327-37. (Pubitemid 32120231)
Bentzen SM. Radiation therapy: intensity modulated, image guided, biologically optimized and evidence based. Radiother Oncol 2005;77: 227-30. (Pubitemid 41785329)