Reference : Fatal overdosage with cisplatin
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Fatal overdosage with cisplatin
Charlier, Corinne mailto [Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique]
Kintz, Pascal [> > > >]
Dubois, Nathalie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Toxicologie clinique >]
Plomteux, Guy mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Journal of Analytical Toxicology
Preston Publications Inc
Yes (verified by ORBi)
[en] cisplatin ; forensic toxicology ; fatal overdosage
[en] This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 micro g/L, respectively. Concentrations in urine and bile were 1038 and 501 micro g/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia.

File(s) associated to this reference

Fulltext file(s):

Restricted access
Charlier_2004_J-Anl-Tox_138.pdfPublisher postprint321.07 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.