Abstract :
[en] Summary : Heroin (or diacetylmorphine), a depressant of the
nervous central system, is a semi-synthetic opiate. Its main
adverse effect, respiratory depression, can lead to death, especially
after an intravenous injection. By loss of tolerance, an
overdose can be lethal following heroin use after a period of
abstinence (voluntary or not). Mortality rate among heroin
users is between 1 and 3%. Addiction, following a regular
and continuous use, occurs in less than a quarter of persons
who ever tried heroine. Heroin addicts often present with
different problems (for instance, a criminal behaviour), without
any obvious link with addiction. For a fraction of the
addicts, addiction becomes a chronic relapsing disease, requiring
a long term maintenance substitution therapy. However,
relapses and sometimes continuous heroin use are frequent.
For treatment resistant and severe heroin addicts, heroinassisted
treatment can be a solution. Despite the numerous
available therapies, heroin is considered to be the drug with
the most negative effects on the user.
Name of the research project :
Projet TADAM, un projet pilote de traitement assisté par diacétylmorphine
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