Article (Scientific journals)
Pathogenèse de l'endométriose
Nisolle, Michelle; Alvarez Gonzalez, Maria-Luz; Colombo, M. et al.
2007In Gynécologie Obstétrique et Fertilité, 35 (9), p. 898-903
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Keywords :
Endometriosis; Angiogenesis; Lymphangiogenesis; Inflammation; Fibrosis
Abstract :
[en] Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are estrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Nisolle, Michelle ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Alvarez Gonzalez, Maria-Luz ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Colombo, M.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
French
Title :
Pathogenèse de l'endométriose
Alternative titles :
[en] Pathogenesis of Endometriosis
Publication date :
September 2007
Journal title :
Gynécologie Obstétrique et Fertilité
ISSN :
1297-9589
Publisher :
Elsevier Science
Volume :
35
Issue :
9
Pages :
898-903
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 June 2009

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