Reference : Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/149196
Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H
English
Bretin, Florian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Warnock, Geoffrey []
Bahri, Mohamed Ali mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Aerts, Joël mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Mestdagh, Nathalie []
Buchanan, Tim []
Valade, Anne []
Mievis, Frédéric mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Giacomelli, Fabrice mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse >]
Salmon, Eric mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Seret, Alain mailto [Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale >]
Plenevaux, Alain mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
7-May-2013
EJNMMI Research
Springer
3
1
35
Yes (verified by ORBi)
International
2191-219X
Heidelberg
Germany
[en] Dosimetry ; Preclinical microPET ; Organ harvesting ; SV2
[en] Background: [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to evaluate the radiation dosimetry of [18F]UCB-H in a preclinical trial and to determine the maximum injectable dose according to guidelines for human biomedical research. The radiation dosimetry was derived by organ harvesting and dynamic micro positron emission tomography (PET) imaging in mice, and the results of both methods were compared.
Methods: Twenty-four male C57BL-6 mice were injected with 6.96 ± 0.81 MBq of [18F]UCB-H, and the biodistribution was determined by organ harvesting at 2, 5, 10, 30, 60, and 120 min (n = 4 for each time point). Dynamic microPET imaging was performed on five male C57BL-6 mice after the injection of 9.19 ± 3.40 MBq of [18F]UCB-H. A theoretical dynamic bladder model was applied to simulate urinary excretion. Human radiation dose estimates were derived from animal data using the International Commission on Radiological Protection 103 tissue weighting factors.
Results: Based on organ harvesting, the urinary bladder wall, liver and brain received the highest radiation dose with a resulting effective dose of 1.88E-02 mSv/MBq. Based on dynamic imaging an effective dose of 1.86E-02 mSv/MBq was calculated, with the urinary bladder wall and liver (brain was not in the imaging field of view) receiving the highest radiation.
Conclusions: This first preclinical dosimetry study of [18F]UCB-H showed that the tracer meets the standard criteria for radiation exposure in clinical studies. The dose-limiting organ based on US Food and Drug Administration (FDA) and European guidelines was the urinary bladder wall for FDA and the effective dose for Europe with a maximum injectable single dose of approximately 325 MBq was calculated. Although microPET imaging showed significant deviations from organ harvesting, the Pearson’s correlation coefficient between radiation dosimetry derived by either method was 0.9666.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/149196
10.1186/2191-219X-3-35
http://www.ejnmmires.com/content/3/1/35

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
2191-219X-3-35.pdfPublisher postprint1.23 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.