[en] PositIon emission tomography using 18-fluorodeoxyglucose (FDG-PET) is an imaging technique based on metabolic criteria rather than morphological criteria. We discuss the contribution of this technique in the field of pulmonary oncology and we summarize our work which has demonstrated the performance capacity of PET: to discriminate the malignant nature of a solitary pulmonary nodule; to improve sensitivity over CT for mediastinal assessment in non-small cell lung cancer; to seRach for distant metastasis in patients with non-small cell lung cancer; to complement CT imaging to better dissociate tumor residue or recurrence from post-therapeutic sequelae in non-small cell lung cancer. Finally, we present different expected progress for the future.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bury, Thierry ; Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique
Daenen, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Duysinx, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Bartsch, Pierre ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Corhay, Jean-Louis ; Université de Liège - ULiège > Pneumologie-Allergologie
Language :
French
Title :
Applications en oncologie thoracique de la TEP--18FDG
Hatanaka M. (1974) Transport of sugar in tumor cell membranes. Biochem Biophys Acta 355:77-104.
Karps J., Muehllehner G., Mankoff D. (1990) Continuous slices PENN-PET: A positron tomograph with volume imaging capability. J Nucl Med 31:617-627.
Strauss L., Conti P. (1991) The applications of PET in clinical oncology. J Nucl Med 32:623-648.
Moretti J.L. (1998) Rappels sur les différentes techniques d'imagerie utilisées en médecine nucléaire. Médecine Nucléaire - Imagerie Fonctionnelle et Métabolique 22:456-464.
Shreve P.D., Stevenson R.S., Deters E.C. (1998) Oncologic diagnosis with 2-{fluorine-18}fluoro-2-deoxy-D-glucose imaging: Dual head coincidence gamma camera versus PET scanner. Radiology 207:431-437.
Weber W.A., Neverve J., Sklarek J. (1999) Imaging of lung cancer with 18FDG: Comparison of a dual-head gamma camera in coincidence mode with a full-ring PET system. Eur J Nucl Med 26:388-395.
Delbeke D., Patton J.A., Martin W.H. (1999) FDG-PET and dual head gamma camera positron coincidence detectin imaging of suspected malignancies and brain disorders. J Nucl Med 40:110-117.
Weinhard K., Kahlborm M., Eriksson L. (1994) The ECAT Exact HR: Performance of a new high resolution positron scanner. J Comput Assist Tomog 18:110-118.
Degrado T.R., Turkington T.G., Williams J.J. (1994) Performance characteristics of a whole-body PET scanner. J Nucl Med 35:1398-1406.
Rigo P., Paulus P., Hustinx R. (1996) Clinical PET in Oncology. GE Medical Systems , Paris; 9.
Midthun D., Swensen S., Pett J. (1992) Clinical strategies for solitary pulmonary nodules. Ann Rev Med 93:195-208.
Bury T., Dowlati A., Paulus P. (1996) Evaluation of the solitary pulmonary nodule by PET imaging. Eur Respir J 9:410-414.
Rigo P., Paulus P., Kaschten B.J. (1996) Oncological applications of positron emission tomography with fluorine-18-fluorodeoxyglucose. Eur J Nucl Med 23:1641-1674.
Shields T. (1990) The significance of ipsilateral mediastinal lymph node metastatic (N2 disease) in non-small cell carcinoma of the lung. J Thorac Cardiovasc Surg 99:48-53.
Bury T., Paulus P., Dowlati A. (1996) Staging of the mediastinum: Value of positron emission tomography imaging in non-small cell lung cancer. Eur Respir J 9:2560-2564.
Bury T., Corhay J.L., Paulus P. (1996) La tomographie à émission de positons dans l'évaluation de l'extension ganglionnaire intra-thoracique du cancer bronchique non petites cellules: Étude préliminaire chez 30 patients. Rev Mal Respir 13:281-286.
Vansteenkiste J.F., Stroobandt S.G., Dupont P.J. (1998) FDG-PET scan in potentially operable non-small cell lung cancer: Do anatometabolic PET-CT fusion images improve the localisation of regional lymph node metastases?. Eur J Nucl Med 25:1495-1501.
Wahl R., Quint L., Greenough R. (1994) Staging of mediastinal non-small cell lung cancer with FDG-PET, CT and fusion images: Prospective preliminary evaluation. Radiology 191:371-377.
Chin R., Ward R., Keyes J. (1995) Mediastinal staging of non-samll cell lung cancer with positron emission tomography. Am J Respir Crit Care Med 152:2090-2096.
Bury T., Dowlati A., Paulus P. (1997) Whole-body 18FDG-PET in the staging of non small cell lung cancer. Eur Respir J 10:2529-2534.
Lewis P., Griffin S., Marsden P. (1994) Whole-body 18F-fluorodeoxyglucose positon emission tomography in preoperative evaluation of lung cancer. Lancet 344:1265-1266.
Valk P.E., Pounds T.R., Hopkins D.M. (1995) Staging lung cancer by PET imaging. Ann Thorac Surg 60:1573-1582.
Bury T., Barreto A., Daenen F., Barthelemy N., Ghaye B., Rigo P. (1998) Fluorine-18 deoxyglucose positron emission tomography for the detection of bone metastases in patients with non-small cell lung cancer. Eur J Nucl Med 25:1244-1247.
Cook G.J.R., Maisey M.N., Fogelman I. (1999) Normal variants, artefacts and interpretative pitfalls in PET imaging with 18F-2-deoxyglucose and 11C-methionine. Eur J Nucl Med 26:1363-1378.
Karp J.S., Adam L.E., Muehllehner G. (1999) A high-resolution GSO-based brain PET camera. Nuclear Science Symposium, Conference Records, IEEE; 21999 1077-1081.
Weber W.A., Wester H.L., Grosu A.L. (2000) O-{2-(18F-fluoroethyl)-L-tyrosine and L-{methyl-11C}} methionine uptake in brain tumors: Initial results of a comparative study. Eur J Nucl Med 27:542-549.
Patz E.F., Lowe V.J., Hoffman J.M., Paine S.S., Harris L.K., Goodman P.C. (1994) Persistent or recurrent bronchogenic carcinoma: Detection with PET and 2-(F-18)-2-deoxy-D-glucose. Radiology 191:379-382.
Inoue T., Kim E.E., Komaki R. (1995) Detecting recurrent of residual lung cancer with FDG-PET. J Nucl Med 37:788-793.
Franck A., Lefkowitz D., Jaeger S. (1995) Decision logic for retreatment of asymptomatic lung cancer recurrence based on PET findings. Int J Radiation Oncology Biol Phys 32:1495-1512.
Bury T., Corhay J.L., Duysinx B. (1999) Value of FDG-PET in detecting residual or recurrent non-small cell lung cancer. Eur Respir J 14:1376-1380.
Charron M., Beyer T., Bohnem N.N. (2000) Image analysis in patients with cancer studied with a combined PET and CT scanner. Clin Nucl Med 25:905-910.
Mankoff D.A., Dehdashti F., Shields A.F. (2000) Characterizing tumors using metabolic imaging: PET imaging of cellular proliferation and steroid receptors. Neoplasia 2:71-88.
Weber W.A., Avril N., Schwaiger M. (1999) Relevance of positon emission tomography (PET) in Oncology. Strahlenther Onkol 175:356-373.
Shields A.F., Grierson J.R., Dohmen B.M. (1998) Imaging proliferation in vivo with (F-18)FLT and PET. Nat Med 4:1334-1336.
Smith-Jones P.M., Stolz B., Bruns C. (1994) Gallium-67/Gallium-68-(DFO)-octreotide- a potential radiopharmaceutical for PET imaging of somatostatin receptor-positive tumors: Synthesis and radiolabelling in vitro and preliminary in vivo studies. J Nucl Med 35:317-325.
Schirrmeister H., Guhlmann A., Kotzerke J. (1999) Early detection and accurate description of extent of metastatic bone disease in breast cancer with fluoride ion and PET. J Clin Oncol 17:2381-2389.
