Article (Scientific journals)
Subversion of complement by hematophagous parasites
SCHROEDER, Hélène; SKELLY, PJ; ZIPFEL, PF et al.
2009In Developmental and Comparative Immunology, 33 (1), p. 5-13
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Abstract :
[en] The complement system is a crucial part of innate and adaptive immunity which exerts a significant evolutionary pressure on pathogens. It has selected for those pathogens, mainly microorganisms but also parasites, that have evolved countermeasures. The characterization of how pathogens evade complement attack is a rapidly developing field of current research. In recent years, multiple complement evasion strategies have been characterized. In this review, we focus on complement escape mechanisms expressed by hematophagous parasites, a heterogeneous group of metazoan parasites that share the property of ingesting the whole blood of their host. Complement inhibition is crucial for parasite survival within the host tissue or to facilitate blood feeding. Finally, complement inhibition by hematophagous parasites may also contribute to their success as pathogen vectors.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
SCHROEDER, Hélène ;  Université de Liège - ULiège > Immunologie - vaccinologie
SKELLY, PJ
ZIPFEL, PF
Losson, Bertrand ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie-Vaccinologie
Language :
English
Title :
Subversion of complement by hematophagous parasites
Publication date :
January 2009
Journal title :
Developmental and Comparative Immunology
ISSN :
0145-305X
Publisher :
Elsevier Science
Volume :
33
Issue :
1
Pages :
5-13
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 May 2013

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