Reference : Subversion of complement by hematophagous parasites
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Subversion of complement by hematophagous parasites
SCHROEDER, Hélène mailto [Université de Liège - ULiège > > Immunologie - vaccinologie > >]
SKELLY, PJ [> >]
ZIPFEL, PF [> >]
Losson, Bertrand mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires > >]
Vanderplasschen, Alain mailto [Université de Liège - ULiège > > Immunologie-Vaccinologie > >]
Developmental and Comparative Immunology
Elsevier Science
Yes (verified by ORBi)
[en] The complement system is a crucial part of innate and adaptive immunity which exerts a significant evolutionary pressure on pathogens. It has selected for those pathogens, mainly microorganisms but also parasites, that have evolved countermeasures. The characterization of how pathogens evade complement attack is a rapidly developing field of current research. In recent years, multiple complement evasion strategies have been characterized. In this review, we focus on complement escape mechanisms expressed by hematophagous parasites, a heterogeneous group of metazoan parasites that share the property of ingesting the whole blood of their host. Complement inhibition is crucial for parasite survival within the host tissue or to facilitate blood feeding. Finally, complement inhibition by hematophagous parasites may also contribute to their success as pathogen vectors.
Researchers ; Professionals

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