Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults

Yakushev, Igor; Chételat, Gael; Fischer F.U.; Lanbeau, Brigitte; Bastin, Christine; Scheurich, Armin; Perrotin, Audrey; Bahri, Mohamed Ali; Drzezga, Alexander; Eustache, Francis; Schreckenberger, Matthias; Fellgiebel, Andreas; Salmon, Eric

doi:10.1016/j.neuroimage.2013.04.069

Article (Scientific journals)

Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults

Yakushev, Igor; Chételat, Gael; Fischer F.U. et al.

2013 • In NeuroImage, 79, p. 184-190

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/147248

DOI
10.1016/j.neuroimage.2013.04.069

PubMed
23631988

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Abstract :

[en] Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes, the posterior cingulate (PCC) and medial prefrontal cortex (MPFC), in relation to normal working memory (WM). DMN was captured using independent component analysis of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) data from 35 young healthy adults (27.1±5.1 years). Metabolic connectivity, a correlation between FDG uptake in PCC and MPFC, was examined in groups of subjects with (relative to median) low (n=18) and high (n=17) performance on digit span backward test as an index of verbal WM. In addition, fiber tractography based on PCC and MPFC nodes as way points was performed in a subset of subjects. FDG uptake in the DMN nodes did not differ between high and low performers. However, significantly (p=0.01) lower metabolic connectivity was found in the group of low performers. Furthermore, as compared to high performers, low performers showed lower density of the left superior cingulate bundle. Verbal WM performance is related to metabolic and structural connectivity within the DMN in young healthy adults. Metabolic connectivity as quantified with FDG-PET might be a sensitive marker of the normal variability in some cognitive functions.

Disciplines :

Neurosciences & behavior

Author, co-author :

Yakushev, Igor

Chételat, Gael

Fischer F.U.

Lanbeau, Brigitte

Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron

Scheurich, Armin

Perrotin, Audrey

Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron

Drzezga, Alexander

Eustache, Francis

More authors (3 more)

Language :

English

Title :

Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults

Publication date :

2013

Journal title :

NeuroImage

ISSN :

1053-8119

eISSN :

1095-9572

Publisher :

Elsevier Science, Orlando, United States - Florida

Volume :

Pages :

184-190

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 April 2013

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