Inhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats

Garbacki, Nancy; Tits, Monique; Angenot, Luc; Damas, Jacques

doi:10.1186/1471-2210-4-25

Article (Scientific journals)

Inhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats

Garbacki, Nancy; Tits, Monique; Angenot, Luc et al.

2004 • In BMC Pharmacology, 4 (1), p. 1-9

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https://hdl.handle.net/2268/14694

DOI
10.1186/1471-2210-4-25

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15498105

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Abstract :

[en] BACKGROUND: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats. RESULTS: Pretreatment of the animals with PACs (10, 30, 60 and 100 mg/kg, i.p.) reduced paw oedema induced by carrageenin in a dose and time-dependent manner. PACs also inhibited dose-dependently carrageenin-induced pleurisy in rats. They reduced (A) lung injury, (B) pleural exudate formation, (C) polymorphonuclear cell infiltration, (D) pleural exudate levels of TNF-alpha, IL-1beta and CINC-1 but did not affect IL-6 and IL-10 levels. They reduced (E) pleural exudate levels of nitrite/nitrate (NOx). In indomethacin treated rats, the volume of pleural exudate was low, its content in leukocytes and its contents in TNF-alpha, IL-1beta, IL-6 and IL-10 but not in NOx were reduced. These data suggest that the anti-inflammatory properties of PACs are achieved through a different pattern from those of indomethacin. CONCLUSION: These results suggest that the main mechanism of the anti-inflammatory effect of PACs mainly lies in an interference with the migration of the leukocytes. Moreover, PACs inhibited in vivo nitric oxide release.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Garbacki, Nancy ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal.

Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie

Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie

Damas, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Language :

English

Title :

Inhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats

Publication date :

21 October 2004

Journal title :

BMC Pharmacology

eISSN :

1471-2210

Publisher :

BioMed Central, United Kingdom

Volume :

Issue :

Pages :

1-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 June 2009

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