Reference : Matrix metalloproteinases at cancer tumor-host interface
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Matrix metalloproteinases at cancer tumor-host interface
Noël, Agnès mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Jost, M. [ > > ]
Maquoi, Erik mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Seminars in Cell & Developmental Biology
Academic Press
Yes (verified by ORBi)
United Kingdom
[en] Stromal proteases ; cancer invasion ; angiogenesis ; inflammation
[en] The increasing diversity in both substrates and functions of matrix metalloproteinases (MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their microenvironment. In the majority of cancers, membrane-associated and extracellular proteases are mainly produced by host cells including inflammatory cells, endothelial cells, pericytes and fibroblasts. Recent data based on in vitro and in vivo studies have demonstrated the relevance of these enzymes in multiple processes controlling cancer growth, angiogenesis and metastatic dissemination. This review will present the emerging MMP-related features of cancer cells and host cells.

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