Evaluation of the residual solvent content of counterfeit tablets and capsules

[en] A group of counterfeit samples of Viagra® and Cialis® were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations did not exceed the international imposed maximum limits. Only in a few samples the limits were exceeded. A Projection Pursuit analysis revealed clusters of samples with similar residual solvent content, possibly enabling some future perspectives in forensic research.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Deconinck, Eric

Canfyn, Michael

Sacre, Pierre-Yves ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Courselle, Patricia

De Beer, Jacques

Language :

English

Title :

Evaluation of the residual solvent content of counterfeit tablets and capsules

Publication date :

July 2013

Journal title :

Journal of Pharmaceutical and Biomedical Analysis

ISSN :

0731-7085

eISSN :

1873-264X

Publisher :

Elsevier Science, Oxford, United Kingdom

Volume :

81-82

Pages :

80-88

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 April 2013

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181 (13 by ULiège)

Number of downloads

10 (8 by ULiège)

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