Reference : Mechanisms of cell migration in the adult brain: modelling subventricular neurogenesis.
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/146176
Mechanisms of cell migration in the adult brain: modelling subventricular neurogenesis.
English
Van Schepdael, An [Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique >]
Ashbourn, J. M. A. [> >]
Beard, R. [> >]
Miller, J. J. [> >]
Geris, Liesbet mailto [Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique >]
2013
Computer Methods in Biomechanics and Biomedical Engineering
Taylor & Francis
Yes (verified by ORBi)
International
1025-5842
1476-8259
London
United Kingdom
[en] Neurogenesis has been the subject of active research in recent years. Although the majority of neurons form during the embryonic period, neurogenesis continues in restricted regions of the mammalian brain well into adulthood. In rodent brains, neuronal migration is present in the rostral migratory stream (RMS), connecting the subventricular zone to the olfactory bulb (OB). The migration in the RMS is characterised by a lack of dispersion of neuroblasts into the surrounding tissues and a highly directed motion towards the OB. This study uses a simple mathematical model to investigate several theories of migration of neuroblasts through the RMS proposed in the literature, including chemo-attraction, chemorepulsion, general inhibition and the presence of a migration-inducing protein. Apart from the general inhibition model, all the models were able to provide results in good qualitative correspondence with the experimental observations.
http://hdl.handle.net/2268/146176
10.1080/10255842.2013.773979

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