Association between Epstein-Barr virus and Hodgkin's lymphoma in Belgium: A pathological and virological study

[en] The association between Epstein-Barr virus (EBV) and classical Hodgkin's lymphoma (cHL) varies according to the geographic location. In this work we sought to characterize EBV involvement in a series of 111 cHL cases diagnosed in Belgium. The overall prevalence of EBV infection detected by in situ hybridization in Reed-Sternberg cells was 33%. EBV positivity correlated with older age at diagnosis (454 years; p = 0.01), mixed cellularity subtype (p = 0.000001), male gender (p = 0.004) and tended to be associated with higher clinical stage (III/IV; p = 0.02). The molecular features of the virus in EBV-positive cHL were studied by comparison with a series of reactive tonsils. A 30-bp deletion within the LMP-1 gene was in 15/28 (53.6%) EBV-positive cHL cases, and in 41.7% of reactive tonsil samples. This variant did not correlate with any clinical or pathological feature. The EBV strain was type A in all cHL and reactive samples.

Disciplines :

Hematology

Author, co-author :

Trimeche, M.

Bonnet, Christophe ; Université de Liège - ULiège > GIGA-R : Hématologie

Korbi, S.

Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

de Leval, Laurence ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Language :

English

Title :

Association between Epstein-Barr virus and Hodgkin's lymphoma in Belgium: A pathological and virological study

Publication date :

2007

Journal title :

Leukemia and Lymphoma

ISSN :

1042-8194

eISSN :

1029-2403

Publisher :

Taylor & Francis Ltd, Abingdon, United Kingdom

Volume :

Issue :

Pages :

1323-1331

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 April 2013

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