Article (Scientific journals)
Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity
Chételat, Gael; Landeau, Brigitte; Salmon, Eric et al.
2013In NeuroImage, 76, p. 167-177
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Abstract :
[en] Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex. The goal of the present study was to assess whether this change was associated with age-related alteration of white matter (WM) structural integrity and/or functional connectivity. FDG-PET data from 40 young and 57 elderly healthy participants from two research centres (n=49/48 in Centre 1/2) were analyzed. WM volume from T1-weighted MRI (Centre 1), fractional anisotropy from diffusion-tensor imaging (Centre 2), and resting-state fMRI data (Centre 1) were also obtained. Group comparisons were performed within each imaging modality. Then, positive correlations were assessed, within the elderly, between metabolism in the most affected region and the other neuroimaging modalities. Metabolism decline in the elderly predominated in the left inferior frontal junction (LIFJ). LIFJ hypometabolism was significantly associated with macrostructural and microstructural WM disturbances in long association fronto-temporo-occipital fibers, while no relationship was found with functional connectivity. The findings offer new perspectives to understand normal aging processes and open avenues for future studies to explore causality between age-related metabolism and connectivity changes.
Disciplines :
Neurosciences & behavior
Author, co-author :
Chételat, Gael
Landeau, Brigitte
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Yakushev, Igor
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Mézenge, Florence
Bastin, Christine  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Manrique, Alain
Scheurich, Armin
Scheckenberger, Mathias
Desgranges, Béatrice
Eustache, Francis
Fellgiebel, Andreas
More authors (3 more) Less
Language :
English
Title :
Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity
Publication date :
2013
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Elsevier Science, Orlando, United States - Florida
Volume :
76
Pages :
167-177
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 March 2013

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