Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

[en] We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

Disciplines :

Genetics & genetic processes

Author, co-author :

Lahortiga, Idoya

De Keersmaecker, Kim

Van Vlierberghe, Pieter

Graux, C.

Cauwelier, B.

Lambert, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

Mentens, N.

Beverloo, H. B.

Pieters, R.

Speleman, F.

More authors (8 more)

Language :

English

Title :

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Publication date :

May 2007

Journal title :

Nature Genetics

ISSN :

1061-4036

eISSN :

1546-1718

Publisher :

Nature Publishing Group, New York, United States - New York

Volume :

Issue :

Pages :

593-595

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 June 2009

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224

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195

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209

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277

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