Article (Scientific journals)
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Lahortiga, Idoya; De Keersmaecker, Kim; Van Vlierberghe, Pieter et al.
2007In Nature Genetics, 39 (5), p. 593-595
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Abstract :
[en] We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
Disciplines :
Genetics & genetic processes
Author, co-author :
Lahortiga, Idoya
De Keersmaecker, Kim
Van Vlierberghe, Pieter
Graux, C.
Cauwelier, B.
Lambert, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Mentens, N.
Beverloo, H. B.
Pieters, R.
Speleman, F.
Odero, M. D.
Bauters, M.
Froyen, G.
Marynen, P.
Vandenberghe, P.
Wlodarska, I.
Meijerink, J. P. P.
Cools, J.
More authors (8 more) Less
Language :
English
Title :
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Publication date :
May 2007
Journal title :
Nature Genetics
ISSN :
1061-4036
eISSN :
1546-1718
Publisher :
Nature Publishing Group, New York, United States - New York
Volume :
39
Issue :
5
Pages :
593-595
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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