Reference : Deciphering supportive treatment strategies for toxic epidermal necrolysis.
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/144061
Deciphering supportive treatment strategies for toxic epidermal necrolysis.
English
Jennes, Serge [Military Hospital Bruxelles > Burn Unit > > >]
PIERARD, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Paquet, Philippe [> >]
2012
Current Drug Safety
7
5
361-6
Yes (verified by ORBi)
International
1574-8863
2212-3911
United Arab Emirates
[en] Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the epidermis. The patient should be promptly addressed to a burn unit where three types of treatment should be administered, namely, (a) specific topical care of the bullous/eroded skin areas, (b) systemic anti-apoptotic/necrotic treatments, and (c) supportive care preventing secondary internal organ failures. This latter aspect is covered by the present review and focuses on (a) early withdrawal of the causative drug, (b) airway management, (c) hydro-electrolytic control, (d) nutritional support, (e) antibiotherapy, (f) prevention of venous thrombosis and gastroduodenal ulcers, and (g) analgesia and anesthesia.
http://hdl.handle.net/2268/144061
10.2174/157488612805076570

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