Reference : Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and H...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/143576
Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.
English
Bogaerts, Pierre [Université Catholique de Louvain - UCL > CHU Mont-Godinne > > >]
Bebrone, Carine mailto [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > >]
Huang, Te-Ding [Université Catholique de Louvain - UCL > CHU Mont-Godinne > > >]
Bouchahrouf, Warda [Université Catholique de Louvain - UCL > CHU Mont-Godinne > > >]
DeGheldre, Yves [Edith Cavell Hospital > Laboratory of Bacteriology, CHIREC > > >]
Deplano, Ariane [ULB University hospital > Laboratory of Bacteriology, Erasme > > >]
Hoffmann, Kurt [Rheinisch - Westfälische Technische Hochschule Aachen - RWTH > > > >]
Glupczynski, Youri [Université Catholique de Louvain - UCL > CHU Mont-Godinne > > >]
Jun-2012
Antimicrobial Agents and Chemotherapy
American Society for Microbiology (ASM)
56(6)
3283-3287
Yes (verified by ORBi)
International
0066-4804
1098-6596
Washington
DC
[en] We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-transferable but not typeable 42-kb plasmid. Compared to values published elsewhere for VIM-2, the purified VIM-31 enzyme showed weaker catalytic efficiency against all the tested beta-lactam agents (except for ertapenem), resulting from lower k(cat) (except for ertapenem) and higher K(m) values for VIM-31.
Alexander von Humboldt Foundation (Germany) - AvH
http://hdl.handle.net/2268/143576
10.1128/AAC.06249-11
We acknowledge the American Society for Microbiology

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