Unpublished conference/Abstract (Scientific congresses and symposiums)
Survival analysis: finding relevant epistatic SNP pairs using Model- Based Multifactor Dimensionality Reduction
Van Lishout, François; Vens, Céline; Urrea, Victor et al.
20125th International Conference of the ERCIM WG on COMPUTING & STATISTICS
 

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Keywords :
Model-Based Multifactor Dimensionality Reduction; Epistasis; Survival analysis
Abstract :
[en] Analyzing the combined effects of genes (and/or environmental factors) on the development of complex diseases is quite challenging, both from the statistical and computational perspective, even using a relatively small number of genetic and non-genetic exposures. Several data-mining methods have been proposed for interaction analysis, among them, the Multifactor Dimensionality Reduction Method (MDR). Model-Based Multifactor Dimensionality Reduction (MB-MDR), a relatively new dimensionality reduction technique, is able to unify the best of both nonparametric and parametric worlds, and has proven its utility in a variety of theoretical and practical settings. Until now, MB-MDR software has only accommodated traits that are measured on a binary or interval scale. Time-to-event data could therefore not be analyzed with the MB-MDR methodology. MB-MDR-3.0.0 overcomes this shortcoming of earlier versions. We show the added value of MB-MDR for censored traits by comparing the implemented strategies with more classical methods such as those based on a parametric regression paradigm. The simulation results are supplemented with an application to real-life data.
Disciplines :
Computer science
Author, co-author :
Van Lishout, François ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Vens, Céline;  K.U. Leuven > Computer Science Department
Urrea, Victor;  University of Vic > Departement of Systems Biology
Calle, M. Luz;  University of Vic > Departement of Systems Biology
Wehenkel, Louis  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Van Steen, Kristel  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Language :
English
Title :
Survival analysis: finding relevant epistatic SNP pairs using Model- Based Multifactor Dimensionality Reduction
Publication date :
03 December 2012
Event name :
5th International Conference of the ERCIM WG on COMPUTING & STATISTICS
Event place :
Oviedo, Spain
Event date :
1-3 December 2012
Audience :
International
Available on ORBi :
since 10 February 2013

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