Simultaneous Reactivation of Herpes Simplex Virus and Varicella-Zoster Virus in a Patient with Idiopathic Thrombocytopenic Purpura

Nikkels, Arjen; Frere, P.; Rakic, L.; Fassotte, Marie-France; Evrard, Brigitte; De Mol, Patrick; Pierard, Gérald

doi:10.1159/000018292

Article (Scientific journals)

Simultaneous Reactivation of Herpes Simplex Virus and Varicella-Zoster Virus in a Patient with Idiopathic Thrombocytopenic Purpura

Nikkels, Arjen; Frere, P.; Rakic, L. et al.

1999 • In Dermatology, 199 (4), p. 361-364

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/14243

DOI
10.1159/000018292

PubMed
10640851

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Keywords :

herpes simplex virus; varicella-zoster virus; idiopathic thrombocytopenic purpura; chemotherapy; immunosuppression

Abstract :

[en] Simultaneous reactivation of distinct Herpesviridae with development of clinical manifestations is exceptional. We report a 48-year-old woman suffering from idiopathic thrombocytopenic purpura. As the disease remained refractory to corticosteroids, immunoglobulins and splenectomy, a cure of vinblastine was administered. An atypical stomatitis developed few days later. Immunohistochemistry on a Tzanck smear and a biopsy evidenced a Herpes simplex virus type 1 (HSV-1) infection. The patient presented simultaneously a single necrotic lesion on the abdomen. Immunohistochemistry on a skin biopsy revealed the presence of the varicella-zoster virus (VZV) gE, gB and IE63 proteins. Intravenous aciclovir was initiated. The present case of simultaneous clinical infections by HSV-I and VZV underlines the importance of complementary viral identification testing in the event of unusual clinical presentations.

Disciplines :

Dermatology

Author, co-author :

Nikkels, Arjen ; Université de Liège - ULiège > Dermatologie

Frere, P.

Rakic, L.

Fassotte, Marie-France ; Université de Liège - ULiège > Hématologie clinique

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

De Mol, Patrick ; Université de Liège - ULiège > Microbiologie médicale

Pierard, Gérald ; Université de Liège - ULiège > Dermatopathologie

Language :

English

Title :

Simultaneous Reactivation of Herpes Simplex Virus and Varicella-Zoster Virus in a Patient with Idiopathic Thrombocytopenic Purpura

Publication date :

1999

Journal title :

Dermatology

ISSN :

1018-8665

eISSN :

1421-9832

Publisher :

S. Karger, Basel, Switzerland

Volume :

199

Issue :

Pages :

361-364

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 March 2010

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Bibliography

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