Reference : Patterns of the Immunohistochemical Expression of Melanoma-Associated Antigens and De...
Scientific journals : Article
Human health sciences : Dermatology
Patterns of the Immunohistochemical Expression of Melanoma-Associated Antigens and Density of Cd45r0+ Activated T Lymphocytes and L1-Protein Positive Macrophages in Primary Cutaneous Melanomas
Pierard-Franchimont, Claudine [Université de Liège - ULiège > > Dermatopathologie >]
Letawe, C. [> > >]
Nikkels, Arjen mailto [Université de Liège - ULiège > > Dermatologie >]
Pierard, Gérald mailto [Université de Liège - ULiège > > Dermatopathologie >]
International Journal of Molecular Medicine
Professor D A Spandidos
Yes (verified by ORBi)
[en] There is ample evidence for spontaneous antimelanoma immune reactivity mediated by melanocyte-differentiation-antigens (MDAs). Our aim was to determine whether MDA immunoreactivity is associated with increased tumour-infiltrating lymphocytes (TIL) and macrophages (TIM). A retrospective study was conducted in 30 medium and high grade primary cutaneous melanomas (PCM) as identified by CART-analysis. All of the cases had developed clinical evidence for metastasis within 3 years following surgical excision of the PCM. We used immunohistochemistry and computerized image analysis to quantify MDAs positive cells (Melan A/MART-1, gp100/Pmel 17/HMB45, tyrosinase), CD45R0-positive TIL and LI-protein-positive TIM. A stochastic relationship was present between the MDA immuno-reactivities and the densities in TIL and TIM. An inverse relationship was yielded between TIL and TIM. No specific pattern of PCM immunoreactivity for MDAs, TIL and TIM was found to predict metastases.

File(s) associated to this reference

Fulltext file(s):

Restricted access
Patterns of the immunohistochemical expression of melanocyte-differentiation antigens and density of CD45R0 + T lymphocytes and L1-protein + macrophages in ....pdfPublisher postprint958.66 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.