Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.

Cherrier, Thomas; Le Douce, Valentin; Redel, Laetitia; Marban, Celine; Aunis, Dominique; Rohr, Olivier; Schwartz, Christian

doi:10.1051/medsci/2010263291

Article (Scientific journals)

Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.

Cherrier, Thomas; Le Douce, Valentin; Redel, Laetitia et al.

2010 • In MS. Medecine Sciences, 26 (3), p. 291-5

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/140682

DOI
10.1051/medsci/2010263291

PubMed
20346279

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Keywords :

Disease Reservoirs; HIV Infections/drug therapy/physiopathology; HIV-1/genetics/physiology; Histone Deacetylase Inhibitors/therapeutic use; Histone Deacetylases/metabolism; Humans; RNA, Messenger/genetics; RNA, Viral/genetics; Virus Latency; Virus Replication

Abstract :

[en] The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Cherrier, Thomas ; Université de Liège - ULiège > GIGA-Research

Le Douce, Valentin

Redel, Laetitia

Marban, Celine

Aunis, Dominique

Rohr, Olivier

Schwartz, Christian

Language :

French

Title :

Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.

Alternative titles :

[en] Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications

Publication date :

2010

Journal title :

MS. Medecine Sciences

ISSN :

0767-0974

eISSN :

1958-5381

Publisher :

Editions EDK, France

Volume :

Issue :

Pages :

291-5

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 January 2013

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