Reference : Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.
[en] Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications
Cherrier, Thomas mailto [Université de Liège - ULiège > GIGA-Research > > >]
Le Douce, Valentin [> >]
Redel, Laetitia [> >]
Marban, Celine [> >]
Aunis, Dominique [> >]
Rohr, Olivier [> >]
Schwartz, Christian [> >]
MS. Medecine Sciences
Yes (verified by ORBi)
[en] Disease Reservoirs ; HIV Infections/drug therapy/physiopathology ; HIV-1/genetics/physiology ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/metabolism ; Humans ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Virus Latency ; Virus Replication
[en] The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary.

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