Article (Scientific journals)
Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.
Cherrier, Thomas; Le Douce, Valentin; Redel, Laetitia et al.
2010In MS. Medecine Sciences, 26 (3), p. 291-5
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Keywords :
Disease Reservoirs; HIV Infections/drug therapy/physiopathology; HIV-1/genetics/physiology; Histone Deacetylase Inhibitors/therapeutic use; Histone Deacetylases/metabolism; Humans; RNA, Messenger/genetics; RNA, Viral/genetics; Virus Latency; Virus Replication
Abstract :
[en] The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Cherrier, Thomas ;  Université de Liège - ULiège > GIGA-Research
Le Douce, Valentin
Redel, Laetitia
Marban, Celine
Aunis, Dominique
Rohr, Olivier
Schwartz, Christian
Language :
French
Title :
Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.
Alternative titles :
[en] Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications
Publication date :
2010
Journal title :
MS. Medecine Sciences
ISSN :
0767-0974
eISSN :
1958-5381
Publisher :
Editions EDK, France
Volume :
26
Issue :
3
Pages :
291-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 January 2013

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