Reference : Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.
[en] Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency
Schwartz, Christian [> >]
Le Douce, Valentin [> >]
Cherrier, Thomas mailto [Université de Liège - ULiège > GIGA-Research > > >]
Redel, Laetitia [> >]
Marban, Celine [> >]
Aunis, Dominique [> >]
Rohr, Olivier [> >]
MS. Medecine Sciences
Yes (verified by ORBi)
[en] DNA, Viral/genetics ; Epigenesis, Genetic ; Gene Expression Regulation, Viral ; HIV Infections/virology ; HIV-1/genetics/physiology ; Host-Pathogen Interactions ; Humans ; Microglia/virology ; Proviruses/genetics/physiology ; RNA, Viral/genetics ; Transcription, Genetic ; Virus Integration ; Virus Latency/genetics/physiology
[en] The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.

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