Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.

Schwartz, Christian; Le Douce, Valentin; Cherrier, Thomas; Redel, Laetitia; Marban, Celine; Aunis, Dominique; Rohr, Olivier

doi:10.1051/medsci/2010262159

Article (Scientific journals)

Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.

Schwartz, Christian; Le Douce, Valentin; Cherrier, Thomas et al.

2010 • In MS. Medecine Sciences, 26 (2), p. 159-63

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/140681

DOI
10.1051/medsci/2010262159

PubMed
20188047

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Keywords :

DNA, Viral/genetics; Epigenesis, Genetic; Gene Expression Regulation, Viral; HIV Infections/virology; HIV-1/genetics/physiology; Host-Pathogen Interactions; Humans; Microglia/virology; Proviruses/genetics/physiology; RNA, Viral/genetics; Transcription, Genetic; Virus Integration; Virus Latency/genetics/physiology

Abstract :

[en] The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Schwartz, Christian

Le Douce, Valentin

Cherrier, Thomas ; Université de Liège - ULiège > GIGA-Research

Redel, Laetitia

Marban, Celine

Aunis, Dominique

Rohr, Olivier

Language :

French

Title :

Un virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.

Alternative titles :

[en] Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency

Publication date :

2010

Journal title :

MS. Medecine Sciences

ISSN :

0767-0974

eISSN :

1958-5381

Publisher :

Editions EDK, France

Volume :

Issue :

Pages :

159-63

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 January 2013

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