Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

Animals; Cattle; Cell Cycle Proteins/genetics; Chromosome Mapping; Crossing Over, Genetic; Genetic Linkage; Genome; Histone-Lysine N-Methyltransferase/genetics; Homologous Recombination/genetics; Humans; Male; Miosis/genetics; Pedigree; Polymorphism, Single Nucleotide; Quantitative Trait Loci/genetics; Sequence Homology, Amino Acid; Sperm Count; Spermatozoa/cytology; Ubiquitin-Protein Ligases/genetics

Abstract :

[en] We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

Disciplines :

Genetics & genetic processes

Author, co-author :

Sandor, Cynthia ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Li, Wanbo ; Université de Liège - ULiège > GIGA - Membres

Coppieters, Wouter ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Druet, Tom ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Charlier, Carole ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

Publication date :

2012

Journal title :

PLoS Genetics

ISSN :

1553-7390

eISSN :

1553-7404

Publisher :

Public Library of Science, United States - California

Volume :

Issue :

Pages :

e1002854

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 January 2013

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133 (2 by ULiège)

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Scopus citations^®

105

Scopus citations^®
without self-citations

OpenCitations

117

OpenAlex citations

136

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