Reference : Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/138747
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
English
Sandor, Cynthia [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Li, Wanbo mailto [Université de Liège - ULiège > > > GIGA - Membres]
Coppieters, Wouter mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Druet, Tom mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Charlier, Carole mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Georges, Michel mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
2012
PLoS Genetics
8
7
e1002854
Yes (verified by ORBi)
International
1553-7390
1553-7404
United States
[en] Animals ; Cattle ; Cell Cycle Proteins/genetics ; Chromosome Mapping ; Crossing Over, Genetic ; Genetic Linkage ; Genome ; Histone-Lysine N-Methyltransferase/genetics ; Homologous Recombination/genetics ; Humans ; Male ; Miosis/genetics ; Pedigree ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci/genetics ; Sequence Homology, Amino Acid ; Sperm Count ; Spermatozoa/cytology ; Ubiquitin-Protein Ligases/genetics
[en] We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/138747
10.1371/journal.pgen.1002854

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