Reference : Changes in functional interactions during anaesthesia-induced loss of consciousness
Scientific congresses and symposiums : Poster
Human health sciences : Multidisciplinary, general & others
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/138402
Changes in functional interactions during anaesthesia-induced loss of consciousness
English
Schrouff, Jessica mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Perlbarg, Vincent []
Boly, Mélanie mailto [Université de Liège - ULiège > Département des sciences cliniques > Neurologie >]
Marrelec, Guillaume []
BOVEROUX, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Bruno, Marie-Aurélie [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Laureys, Steven [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Phillips, Christophe [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Pélégrini-Issac, Mélanie []
Maquet, Pierre [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Benali, Habib []
12-Dec-2010
A0
Yes
No
International
Workshop on Connectivity Inference in Neuroimaging
from 07-12-2009 to 12-12-2009
Neural Information Processing Systems
Vancouver
Canada
[en] functional connectivity ; anaesthesia ; integration
[en] Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness.
Centre de Recherches du Cyclotron - CRC ; Laboratoire d'Imagerie Fonctionnelle, INSERM, UPMC-Paris 6, Paris
Fonds Fernand Pisart ; University of Liège ; Erasmus project
Researchers ; Professionals
http://hdl.handle.net/2268/138402
http://cini2009.kyb.tuebingen.mpg.de/

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