Contribution of whole-body (18)FDG PET imaging in the management of cervical cancer

[en] OBJECTIVE: The objective of this study was to assess the contribution of [(18)F]fluoro-2-deoxy-D-glucose positron emission tomography ((18)FDG PET) imaging in the management of cervical cancer. METHODS: Fully corrected whole-body PET was performed in 60 patients (pts) with proven cervical cancer. In pretreatment staging, 22 pts underwent PET in addition to routine protocol including International Federation of Obstetrics and Gynecology (FIGO) staging and pelvic magnetic resonance imaging (MRI). Eighteen of them had pelvic lymphadenectomy. After treatment, PET was performed in 38 pts routinely followed up by clinical and radiological examinations. Results of PET and routine protocols were compared to final diagnoses, including histological findings in 31 pts and clinical outcomes in the other cases. Median follow-up time was 12 +/- 7.3 months. RESULTS: In all but 2 patients (FIGO stage IA), both PET and MRI detected the primary tumor. In 6 pts, MRI alone noted loco-regional tumor spread but PET localized 9 unsuspected extrapelvic nodal sites (6 para-aortic, 2 mediastinal, and 1 supra-clavicular). However, PET missed 8 microscopic pelvic nodal metastases. In 18% of the patients, PET staging significantly influenced the treatment choices. In follow-up, PET accurately diagnosed a recurrent disease in 13 pts with falsely negative or equivocal conventional imaging (CI). Ten patients with a negative PET were still in complete remission after a minimal follow-up time of 12 months. Overall, the agreement of PET with final diagnosis was significantly better than that of routine protocol (P < 0.05). CONCLUSIONS: Whole-body (18)FDG PET appears useful in the management of cervical cancer, in particular for staging extrapelvic metastases or optimally detecting a recurrence. MRI is better indicated for evaluating the loco-regional status of the disease.

Disciplines :

Oncology
Reproductive medicine (gynecology, andrology, obstetrics)

Author, co-author :

Belhocine, T.

Thille, Alain ; Centre Hospitalier Universitaire de Liège - CHU > Imagerie médicale

Fridman, Viviana ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique

Seidel, Laurence ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique

Nickers, Philippe ; Université de Liège - ULiège > Département des sciences cliniques

Kridelka, Frédéric ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie et obstétrique

Rigo, Pierre ; Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire

Language :

English

Title :

Contribution of whole-body (18)FDG PET imaging in the management of cervical cancer

Publication date :

October 2002

Journal title :

Gynecologic Oncology

ISSN :

0090-8258

eISSN :

1095-6859

Publisher :

Academic Press Inc Elsevier Science, San Diego, United States - California

Volume :

Issue :

Pages :

90-97

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 January 2013

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Scopus citations^®

110

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105

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115

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