Bronchodilators in bronchoscopy-induced airflow limitation in allergen-sensitized cats.

[en] This study investigated the effect of bronchoscopy and bronchoalveolar lavage (BAL) on respiratory function, determined by barometric whole-body plethysmography (BWBP), of healthy and allergen-sensitized cats. Furthermore, the efficacy of inhaled bronchodilators in preventing changes in respiratory function was determined. For test 1, 18 healthy experimental cats were investigated on day 1 by BWBP. On day 2, the cats underwent BWBP after sedation (medetomidine), after anesthesia induction (propofol), and after bronchoscopy and BAL. Enhanced pause (Penh) was significantly increased after bronchoscopy and BAL (1.64 +/- 0.17 versus 1.23 +/- 0.07, P < .05). For test 2, 6 cats were sensitized to ovalbumin (OVA), 6 cats were sensitized to Ascaris suum (AS), and 6 cats served as controls. On day 0, OVA- and AS-sensitized cats underwent an inhaled allergen challenge, whereas controls were exposed to saline. On days 1 and 2, the same protocol as described for test 1 was repeated. Post-BAL Penh of the AS-sensitized cats was significantly higher than at test 1 (2.28 +/- 0.22 versus 1.69 +/- 0.33, P < .05) and was correlated with BAL fluid neutrophil count (r = 0.55, P < .05). During tests 3, 4, and 5, the same protocol as used for test 2 was applied to each cat group, with the animals being randomly treated before sedation with inhaled salbutamol (200 microg), ipratropium bromide (40 microg), or a combination of both (200 + 40 microg). Post-BAL Penh of the AS-sensitized group was significantly decreased after the salbutamol + ipratropium bromide treatment (1.56 +/- 0.18 versus 2.28 +/- 0.22, P < .05). This study suggests that bronchoscopy and BAL induce airflow limitation in cats, which is more severe in the presence of lower airway inflammation. Inhaled salbutamol + ipratropium bromide reduce BAL-induced bronchoconstriction in AS-challenged cats and might be recommended as preventive treatment of asthmatic cats undergoing bronchoscopy

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Kirschvink, Nathalie

Leemans, Jérôme ; Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie

Delvaux, François

Snaps, Frédéric ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Imagerie médicale

Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux

Gustin, Pascal ; Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie

Language :

English

Title :

Bronchodilators in bronchoscopy-induced airflow limitation in allergen-sensitized cats.

Publication date :

2005

Journal title :

Journal of Veterinary Internal Medicine

ISSN :

0891-6640

eISSN :

1939-1676

Publisher :

Allen Press, Lawrence, United States - Kansas

Volume :

Issue :

Pages :

161-167

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 June 2009

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Bibliography

Corcoran BM, Foster DJ, Fuentes VL. Feline asthma syndrome: A retrospective study of the clinical presentation in 29 cats. J Small Anim Pract 1995;36:481-488.
Dye JA, McKiernan BC, Rozanski EA, et al. Bronchopulmonary disease in the cat: Historical, physical, radiographic, clinicopathologic, and pulmonary functional evaluation of 24 affected and 15 healthy cats. J Vet Intern Med 1996;10:385-400.
Padrid PA. Feline asthma: Diagnosis and treatment. Clin North Am Small Anim Pract 2000;30:1279-1294.
Andreasen CB. Bronchoalveolar lavage. Vet Clin North Am Small Anim Pract 2003;33:69-88.
Hawkins EC. Bronchoalveolar lavage. In: King LG, ed. Respiratory Disease in Dogs and Cats. St Louis, MO: WB Saunders; 2004:118-128.
Hoffman AM, Dhupa N, Cimetti L. Airway reactivity measured by barometric whole-body plethysmography in healthy cats. Am J Vet Res 1999;60:1487-1492.
Rozanski KA, Hoffman AM. Lung mechanics using plethysmography and spirometry. In: King LG, ed. Respiratory Disease in Dogs and Cats. St Louis, MO: WB Saunders; 2004:175-193.
Hamelmann H, Schwarze J, Takeda A, et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766-775.
Hirt RA, Dederichs D, Boehler A, Hoffman AM. Relationship of age, Sex, body weight, and hematologic and respiratory variables with airway reactivity in adult cats. Am J Vet Res 2003;64:26-31.
Halloy D, Kirschvink N, Vincke G, et al. Whole body barometric plethysmography: A screening method to investigate airway reactivity and acute lung injuries in freely moving pigs. Vet J 2004;68:276-284.
Hirt R, Dederichs D. Quantification of bronchoconstriction and response to nebulized beta2-bronchodilators in spontaneously occurring feline asthma. Federation of European Companion Animal Veterinary Associations 7th Annual Meeting, Berlin, Germany. October 25-28, 2001.
Vesco D, Kleisbauer JP, Orehek J. Attenuation of bronchofiberscopy- induced cough by an inhaled beta 2-adrenergic agonist, fenoterol. Am Rev Respir Dis 1988;138:805-806.
Djukanovic R, Wilson JW, Lai CK, et al. The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma. Am Rev Respir Dis 1991;143:772-777.
Van Vyve T, Chanez P, Bousquet J, et al. Safety of bronchoalveolar lavage and bronchial biopsies in patients with asthma of variable severity. Am Rev Respir Dis 1992;146:116-121.
Humbert M, Robinson DS, Assoufi B, et al. Safety of fibreoptic bronchoscopy in asthmatic and control subjects and effect on asthma control over two weeks. Thorax 1996;51:664-669.
Inoue H, Aizawa H, Takata S, et al. Ipratropium bromide protects against bronchoconstriction during bronchoscopy. Lung 1994;172:293-298.
Williams T, Brooks T, Ward C. The role of atropine premedication in fiberoptic bronchoscopy using intravenous midazolam sedation. Chest 1998;113:1394-1398.
Cowl CT, Prakash UB, Kruger BR. The role of anticholinergics in bronchoscopy. A randomized clinical trial. Chest 2000;118:188-192.
Honeybourne D, Babb J, Bowie P, et al. British Thoracic Society guidelines on diagnostic flexible bronchoscopy. Thorax 2001;56(Suppl 1):i1-21.
Jeffery P, Holgate S, Wenzel S. Methods for the assessment of endobronchial biopsies in clinical research: Application to studies of pathogenesis and the effects of treatment. Am J Respir Crit Care Med 2003;168:S1-S17.
Kirschvink N, Marlin D, Delvaux F, et al. Collection of exhaled breath condensate and analysis of hydrogen peroxide as a potential marker of lower airway inflammation in cats. Vet J 2005. In press.
Padrid PA, Snook S, Finucane T, et al. Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats. Am J Respir Crit Care Med 1995;151:184-193.
Peeters DE, McKiernan BC, Weisiger RM, et al. Quantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in dogs. J Vet Intern Med 2000;14:534-541.
Groeben H, Mitzner W, Brown RH. Effects of the alpha2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs. Anesthesiology 2004;100:359-363.
Chetta A, Foresi A, Bertorelli G, et al. Lung function and bronchial responsiveness after bronchoalveolar lavage and bronchial biopsy performed without premedication in stable asthmatic subjects. Chest 1992;101:1563-1568.
Hawkins EC, DeNicola DB. Collection of bronchoalveolar lavage fluid in cats using an endotracheal tube. Am J Vet Res 1989;50:855-859.
Haczku A, Moqbel R, Elwood W, et al. Effects of prolonged repeated exposure to ovalbumin in sensitized brown Norway rats. Am J Respir Crit Care Med 1994;150:23-27.
Leung SY, Eynott P, Noble A, et al. Resolution of allergic airways inflammation but persistence of airway smooth muscle proliferantion after repeated allergen exposures. Clin Exp Allergy 2004; 34:213-220.
Sheth KK, Lemanske RF, Jr. The early end late asthmatic response to allergen. In: Holgate ST, Busse WW, ed. Lung Biology in Health and Disease: Inflammatory Mechanisms in Asthma, Vol 117. New York, NY: Marcel Dekker; 1998:805-821.
Norris CR, Byerly JR, Decile KC, et al. Allergen-specific IgG and IgA in serum and bronchoalveolar lavage fluid in a model of experimental feline asthma. Vet Immunol Immunopathol 2003;96:119-127.
Hirt RA. Felines Asthma bronchiale - Uberblick und neue Erkenntnisse. Vet Med Austria 2003;90:110-123.