Reference : Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the re...
Scientific congresses and symposiums : Poster
Human health sciences : Oncology
http://hdl.handle.net/2268/137687
Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
English
Barez, Pierre-Yves mailto [Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc. >]
22-Jun-2012
No
National
GIGA-Cancer Day 2012
22 Juin 2012
Université de Liège - Ecole Doctorale Thématique en Cancérologie Expérimentale & GIGA Cancer
Liège
Belgique
[en] HTLV-1 ; Tax ; MCM2-7 ; Replication timing
[en] First human retrovirus discovered, HTLV-1 infects approximately twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most important are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). We are interested in the mechanisms of transformation by the viral Tax oncoprotein. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). Thereby, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. In fact, Tax accelerates S phase progression by inducing early firing of late replication origins. Concomitantly, Tax-MCM2-7 interplay also modulates viral transcription. Together, our data demonstrates that interaction between Tax and MCM2-7 is involved in replication reprogramming and viral transcription.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/137687

File(s) associated to this reference

Additional material(s):

File Commentary Size Access
Restricted access
Poster GIGA Cancer Day 2012.pptx7.12 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.