Reference : Thyrotropin-Secreting Pituitary Adenomas: Report of Seven Cases
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Thyrotropin-Secreting Pituitary Adenomas: Report of Seven Cases
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie]
Abs, R. [ > > ]
Mahler, C. [ > > ]
Vandalem, J. L. [ > > ]
Pirens, G. [ > > ]
Hennen, Georges [Université de Liège - ULiège > > Endocrinologie clinique >]
Stevenaert, Achille [Université de Liège - ULiège > > Neurochirurgie >]
Journal of Clinical Endocrinology and Metabolism
Endocrine Society
Yes (verified by ORBi)
Chevy Chase
[en] Adenoma/complications/secretion/therapy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bromocriptine/diagnostic use ; Circadian Rhythm ; Female ; Glycoprotein Hormones, alpha Subunit/blood ; Growth Hormone/blood ; Humans ; Hyperthyroidism/drug therapy/etiology ; Male ; Methimazole/diagnostic use/therapeutic use ; Middle Aged ; Octreotide/therapeutic use ; Pituitary Neoplasms/complications/secretion/therapy ; Prolactin/blood ; Thyrotropin/blood/secretion ; Thyrotropin-Releasing Hormone/diagnostic use
[en] Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied between 1.1-36.3 mU/L. The serum alpha-subunit level was low in 1 case, while in 4 other cases the concentration was elevated and varied between 3.7-7.8 micrograms/L. Serum TSH beta levels were normal in the 4 cases in which it was determined. Serum GH or PRL levels were elevated in 5 cases. In 1 patient the cosecretion of TSH, GH, and PRL was confirmed by immunocytochemical examination. Serum TSH and alpha-subunit responses to TRH, GnRH, CRF, GRF, dexamethasone, methimazole, T3, and bromocriptine administration were variable when studied. Serum TSH and alpha-subunit circadian rhythms were absent in 1 case and inverted in another. A serum alpha-subunit pulsatility without TSH pulses was observed in 1 patient. Five patients underwent transsphenoidal adenomectomy. Three of 4 patients operated on in our center were cured, but a recurrence of the adenoma was found in 1 of them after 5 yr. The fifth patient was not cured. Treatment with octreotide in 3 patients resulted in normalization of serum TSH, GH, and thyroid hormones levels. Cosecretion of PRL in 1 case and alpha-subunit in 2 cases was also inhibited. Partial tachyphylaxis occurred in 1 patient. In summary, heterogeneity in clinical presentation, hormonal expression, and therapeutic response appears to characterize these TSH-secreting adenomas.
Researchers ; Professionals

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