Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization

Ouédraogo, M; Semdé, R; Somé, I.T; Traoré Ouédraogo, R; Guissou, I.P; Henschel, V; Dubois, J; Amighi, K; Evrard, Brigitte

doi:10.1080/03639040801926287

Article (Scientific journals)

Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization

Ouédraogo, M; Semdé, R; Somé, I.T et al.

2008 • In Drug Development and Industrial Pharmacy, 34, p. 753-760

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/13631

DOI
10.1080/03639040801926287

PubMed
18627115

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Abstract :

[en] To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Ouédraogo, M

Semdé, R

Somé, I.T

Traoré Ouédraogo, R

Guissou, I.P

Henschel, V

Dubois, J

Amighi, K

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Language :

English

Title :

Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization

Publication date :

2008

Journal title :

Drug Development and Industrial Pharmacy

ISSN :

0363-9045

eISSN :

1520-5762

Publisher :

Taylor & Francis, Philadelphia, United States - Pennsylvania

Volume :

Pages :

753-760

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 May 2010

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