Article (Scientific journals)
Modelling the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on the immune system response of a HIV-infected patient
Stan, Guy-Bart; Belmudes, Florence; Fonteneau, Raphaël et al.
2008In IET Systems Biology, 2 (2), p. 94-102
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Keywords :
HIV; mathematical modelling; apoptosis
Abstract :
[en] On the basis of the human immunodeficiency virus (HIV) infection dynamics model proposed by Adams, the authors propose an extended model that aims at incorporating the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on the immune system response of HIV-infected patients. Through this model, the authors study the influence of this phenomenon on the time evolution of specific cell populations such as plasma concentrations of HIV copies, or blood concentrations of CD4+ and CD8+ T-cells. In particular, this study shows that depending on its intensity, the apoptosis phenomenon can either favour or mitigate the long-term evolution of the HIV infection.
Disciplines :
Immunology & infectious disease
Computer science
Author, co-author :
Stan, Guy-Bart
Belmudes, Florence ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Fonteneau, Raphaël ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Zeggwagh, Frédéric
Lefebvre, Marie-Anne
Michelet, Christian
Ernst, Damien  ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Language :
English
Title :
Modelling the influence of activation-induced apoptosis of CD4+ and CD8+ T-cells on the immune system response of a HIV-infected patient
Publication date :
March 2008
Journal title :
IET Systems Biology
ISSN :
1751-8849
Publisher :
Institution of Engineering & Technology
Volume :
2
Issue :
2
Pages :
94-102
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 June 2009

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