Article (Scientific journals)
Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare
Sahpaz, S.; Garbacki, Nancy; Tits, Monique et al.
2002In Journal of Ethnopharmacology, 79 (3), p. 389-392
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Keywords :
Marrubium vulgare; phenylpropanoid esters; anti-inflammatory activity; cyclooxygenase
Abstract :
[en] The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their anti-inflammatory activity are reported for the first time, We evaluated the inhibitory effects of these five compounds on cyclooxygenase (Cox) catalysed prostaglandin biosynthesis activity. Only the glycosidic phenylpropanoid esters showed an inhibitory activity towards the Cox-2 enzyme and three of them: acteoside 2, forsythoside B 3, arenarioside 4, exhibited higher inhibitory potencies on Cox-2 than on Cox-1. These results are of interest, as Cox-2 is mainly associated with inflammation and the Cox-1 inhibition with adverse side effects often observed with non-steroidal anti-inflammatory drugs. The occurence of these phenylpropanoid esters could also explain some other pharmacological properties of M. vulgare. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Disciplines :
Pharmacy, pharmacology & toxicology
Phytobiology (plant sciences, forestry, mycology...)
Chemistry
Author, co-author :
Sahpaz, S.
Garbacki, Nancy  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal.
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Bailleul, F.
Language :
English
Title :
Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare
Publication date :
March 2002
Journal title :
Journal of Ethnopharmacology
ISSN :
0378-8741
eISSN :
1872-7573
Publisher :
Elsevier Sequoia, Limerick, Ireland
Volume :
79
Issue :
3
Pages :
389-392
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 June 2009

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