[en] Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production.
Cortelazzo S, Viero P, Finazzi G. Incidence and risk factors for thrombotic complications in historical cohort of 100 patients with essential thrombocythemia. J Clin Oncol 1990 ; 8 : 556-62.
Beutler E, Lichtman M, Coller B. Williams Hematology, Fifth edition. New York: McGraw-Hill, 1995 : 340-4.
Hehlmann R, John M, Baumann B, Köpeke W. Essential thrombocythemia. Clinical characteristics and course of 61 cases. Cancer 1988 ; 61 : 2487-94.
Murphy S, Iland H, Rosenthal D, Laszlo J. Essential thombocythemia : An interim report from the Polycythemia Vera Study Group. Semin Hematol 1986 ; 23 : 177-82.
Cortelazzo S, Finazzi G, Ruggeri M. Hydroxyurea for patients with essential thrombocythemia and high risk of thrombosis. N Engl J Med 1995 ; 332 : 1132-6.
MacIntyre K, Hoagland H, Silverstein M, Petitt R. Essential thrombocythemia in young adults. Mayo Clin Proc 1991 ; 66 : 149-54.
Giles F, Singer C, Gray A, et al. Alpha-interferon therapy for essential thrombocythaemia. Lancet 1988 ; 2 : 70-6.
Gisslinger H, Chott A, Scheithauer H, et al : Interferon in essential thrombocythaemia. Br J Haematol 1991 ; 79 (Suppl. 1) : 42-8.
Silverstein M, Petitt R, Solberg L, et al. (Anagrelide Study Group). Anagrelide, a therapy for thrombocythemic states : Experience in 577 patients. Am J Med 1992 ; 92 : 69-76.
Alving B, Coller B, Duffy T, et al. Platelets : Pharmacologic and transfusion strategies to alter function and production. ASH educational program, 37th meeting of the American Society of hematology, Seattle, december 2-5, 1995.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.