[en] Alfaxalone, a synthetic neuroactive steroid, has been shown to induce smooth general anesthesia in wild and companion rabbits. The aim of the study was to test the effect of alfaxolone in experimental rabbits without concomitant oxygen supplementation.Respiratory status was assessed by measuring the duration of the post-induction apnea, the respiratory rate, the oxygen saturation of hemoglobin in the peripheral blood (SpO2) and the end-tidal CO2 (EtCO2) Cardiac function was assessed by monitoring heart rate using a pulse oximeter. The degree of anesthesia was monitored by evaluating ear and paw pinch reflex, as well as ocular signs such as nystagmus, exophtalmia and the loss of palpebral and corneal reflexes.
Research Center/Unit :
Faculty of Veterinary Medicine Liège Faculty of Veterinary Medicine Bucharest Giga-ULiège
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Tutunaru, Alexandru-Cosmin ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie et réanimation vétérinaires
Sonea, P
Drion, Pierre ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
Duwez, Luc ; Université de Liège - ULiège > GIGA-R : Services généraux de l'Université
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Sandersen, Charlotte ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Language :
English
Title :
Clinical aspects of alfaxalone use in rabbits. Partial results.
Publication date :
15 October 2012
Event name :
"Sharing is Caring": New debates within the European Laboratory Animal Community
