Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

[en] The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. This Review first addresses our current understanding of the nucleic acid-sensing immune machinery. We then explain how the study of nucleic acid-sensing mechanisms not only has revealed their central role in driving the responses mediated by many current vaccines, but is also revealing how they could be harnessed for the design of new vaccines.

Disciplines :

Immunology & infectious disease

Author, co-author :

Desmet, Christophe ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie

Ishii, Ken J.

Language :

English

Title :

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

Publication date :

2012

Journal title :

Nature Reviews. Immunology

ISSN :

1474-1733

eISSN :

1474-1741

Publisher :

Nature Publishing Group, United Kingdom

Volume :

Issue :

Pages :

479-491

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://dx.doi.org/10.1038/nri3247

Available on ORBi :

since 21 September 2012

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316

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293

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302

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