Rapid control of male typical behaviors by brain-derived estrogens

[en] Beside their genomic mode of action, estrogens also activate a variety of cellular signaling pathways through non-genomic mechanisms. Until recently, little was known regarding the functional significance of such actions in males and the mechanism that control local estrogen concentration with a spatial and time resolution compatible with these non-genomic actions had rarely been examined. Here, we review evidence that estrogens rapidly modulate a variety of behaviors in male vertebrates. Then, we present in vitro work supporting the existence of a control mechanism of local brain estrogen synthesis by aromatase along with in vivo evidence that rapid changes in aromatase activity also occur in a region-specific manner in response to changes in the social or environmental context. Finally, we suggest that the brain estrogen provision may also play a significant role in females. Together these data bolster the hypothesis that brain-derived estrogens should be considered as neuromodulators.

Research Center/Unit :

Giga-Neurosciences - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Cornil, Charlotte ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Ball, Gregory F

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Language :

English

Title :

Rapid control of male typical behaviors by brain-derived estrogens

Publication date :

2012

Journal title :

Frontiers in Neuroendocrinology

ISSN :

0091-3022

eISSN :

1095-6808

Publisher :

Academic Press, Orlando, United States - Florida

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science/article/pii/S0091302212000350?v=s5

Funders :

NIH - National Institutes of Health
F.R.S.-FNRS - Fonds de la Recherche Scientifique
ULiège - Université de Liège

Available on ORBi :

since 18 September 2012

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