biomaterial; nanomedicine; self-assembly in solution; stimuli responsive micelle; pH-sensitive polymer
Abstract :
[en] The use of hybrid pH-sensitive micelles mainly based on the PEO129-P2VP43-PCL17 ABC miktoarm star copolymer as potential triggered drug delivery systems has been investigated. Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (poly-2-vinylpyridine, P2VP) has been considered here in order to impart possible active targeting of the tumor cells. Two architectures have been studied for these labeled copolymers, i.e. a miktoarm star or a linear ABC terpolymer and the respective hybrid micelles have been compared in terms of cytotoxicity (cells viability) and cellular uptake (by using fluorescent dye loaded micelles). Finally, the triggered drug release in the cytosol of tumor cells was investigated by studying on one hand the lysosomal integrity after internalization and on the other hand the release profile in function of the pH.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Cajot, Sébastien; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Van Butsele, Kathy; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Paillard, A.; University of Angers (France) > INSERM
Passirani, C.; University of Angers (France) > INSERM
Garcion, E.; University of Angers (France) > INSERM
Benoit, J.-P.; University of Angers (France) > INSERM
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Critical editor :
Varshney, S. K.; Polymer Source, Dorval, Canada
Language :
English
Title :
Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs
BELSPO - Politique scientifique fédérale FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture Ligue Nationale Contre le Cancer
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