Reference : Differential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic beta cells
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Differential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic beta cells
Ortis, Fernanda mailto []
Miani, M []
Colli, ML []
Cunha, DA []
Gurzov, EN []
Allagnat, F []
Chariot, Alain mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Eizirik, Decio L []
FEBS Letters
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] NF-kappa B ; Pancreatic beta cells
[en] The cytokines interleukin (IL)-1b and tumor necrosis factor (TNF)-a induce b-cell death in type 1 diabetes via NF-kB activation. IL-1b induces a more marked NF-kB activation than TNF-a, with higher expression of genes involved in b-cell dysfunction and death. We show here a differential usage of the IKK complex by IL-1b and TNF-a in b-cells. While TNF-a uses IKK complexes containing both IKKa and IKKb, IL-1b induces complexes with IKKa only; this effect is achieved by induction of IKKb degradation via the proteasome. Both IKKg and activation of the TRAF6-TAK1-JNK pathway are involved in IL-1b-induced IKKb degradation.
Giga-Signal Transduction
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students

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