Malignant melanoma and its stromal nonimmune microecosystem.

[en] In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal extracellular matrix (ECM). Stromal cells store and release various structural ECM components. The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM products. This paper summarizes some peculiar aspects of the peri-CMM stroma showing intracytoplasmic loads in Factor XIIIa, CD34, versican, and alpha (IV) collagen chains. The restricted peri-CMM skin territory exhibiting such changes corresponds to the area showing neoangiogenesis and extravascular unicellular metastatic spread. The latter inconspicuous migratory CMM cells possibly correspond to CMM stem cells or to CMM cells with aberrant HOX gene expression. Their presence is associated with an increased risk for metastases in the regional sentinel lymph nodes. In conclusion, the CMM-stroma connection appears crucial to the growth regulation, invasiveness and initial metastatic spread of CMM cells. Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells.

Disciplines :

Dermatologie

Auteur, co-auteur :

PIERARD, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Franchimont, Claudine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Langue du document :

Anglais

Titre :

Malignant melanoma and its stromal nonimmune microecosystem.

Date de publication/diffusion :

2012

Titre du périodique :

Journal of Oncology

ISSN :

1687-8450

eISSN :

1687-8469

Maison d'édition :

Hindawi Publishing Corporation, Egypte

Volume/Tome :

2012

Pagination :

584219

Peer reviewed :

Peer reviewed vérifié par ORBi

Disponible sur ORBi :

depuis le 22 juin 2012

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89 (dont 15 ULiège)

Nombre de téléchargements

301 (dont 7 ULiège)

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